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Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease
Sun, Yu1,2; Wang, Yafei1; Lu, Jiaming3; Liu, Rengyuan4; Schwarz, Christopher G.5; Zhao, Hui4; Zhang, Yue1; Xu, Lingyi1; Zhu, Bin3; Zhang, Bing3; Liu, Bing6; Wan, Suiren1; Xu, Yun4
2017-11-17
发表期刊ONCOTARGET
卷号8期号:58页码:99112-99124
文章类型Article
摘要Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n= 33), mild cognitive impairment (MCI group, n= 31) and Alzheimer's disease (AD group, n= 27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy= 100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD.
关键词Functional Connectivity Perirhinal Cortex Parahippocampal Cortex Ad Mci
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.17944
关键词[WOS]MEDIAL TEMPORAL-LOBE ; WORKING GROUP ; MEMORY ; PARCELLATION ; MODEL
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571040 ; Provincial Natural Science Foundation of Jiangsu(BK20131085) ; Provincial postdoctoral project(1501076A) ; project of the sixth peak of talented people(WSN-O50) ; key project of Nanjing Health Bureau(ZKX14027) ; Jiangsu Province Medical Key talent people ; 12th five years plan for China development(20112016 ; 81300925) ; RC2011013)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000419392300114
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21947
专题脑网络组研究中心
作者单位1.Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Jiangsu, Peoples R China
2.Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England
3.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Radiol, Nanjing, Jiangsu, Peoples R China
4.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
5.Mayo Clin & Mayo Fdn, Dept Radiol, Rochester, MN USA
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
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Sun, Yu,Wang, Yafei,Lu, Jiaming,et al. Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease[J]. ONCOTARGET,2017,8(58):99112-99124.
APA Sun, Yu.,Wang, Yafei.,Lu, Jiaming.,Liu, Rengyuan.,Schwarz, Christopher G..,...&Xu, Yun.(2017).Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease.ONCOTARGET,8(58),99112-99124.
MLA Sun, Yu,et al."Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease".ONCOTARGET 8.58(2017):99112-99124.
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