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"All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration
Yan, Hao1,2; Shang, Wenting3; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Jingyun1; Xiong, Zhiyuan1; Yuan, Jie1; Zhang, Ranran1; Huang, Qianli1; Wang, Kun3; Li, Baohua2; Tian, Jie3; Kang, Feiyu1,2; Feng, Si-Shen4
Source PublicationADVANCED FUNCTIONAL MATERIALS
2018-02-28
Volume28Issue:9
SubtypeArticle
AbstractGreat efforts have been devoted so far to combine nano-magnetic hyperthermia and nano-photothermal therapy to achieve encouraging additive therapeutic performance in vitro and in vivo with limitation to direct intratumoral injection and no guidance of multimodality molecular imaging. In this study, a novel multifunctional theranostic nanoplatform (MNP@PES-Cy7/2-DG) consisting of magnetic nanoparticles (MNPs), poly(3,4-ethylenedioxythiophene): poly(4-styre-nesulfonate) (PES), Cyanine7 (Cy7), and 2-deoxyglucose (2-DG)-polyethylene glycol is developed. They are then applied to combined photo-magnetic hyperthermia therapy under intravenous administration that is simultaneously guided by trimodality molecular imaging. Remarkably, nanoparticles are found aggregated mainly in the cytoplasm of tumor cells in vitro and in vivo, and exhibit stealth-like behavior with a long second-phase blood circulation half-life of 20.38 +/- 4.18 h. Under the guidance of photoacoustic/near-infrared fluorescence/magnetic resonance trimodality imaging, tumors can be completely eliminated under intracellular photo-magnetic hyperthermia therapy with additive therapeutic effect due to precise hyperthermia. This study may promote a further exploration of such a platform for clinical applications.
KeywordBreast Cancer Hyperthermia Molecular Imaging Nanomedicine Nanotheranostics
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201705710
WOS KeywordIRON-OXIDE NANOPARTICLES ; PHOTOTHERMAL THERAPY ; PROSTATE-CANCER ; POLYPYRROLE NANOPARTICLES ; COMBINATION THERAPY ; DRUG CARRIER ; THERMOTHERAPY ; FEASIBILITY ; NANOCOMPOSITES ; EFFICIENCY
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China(2016YFB0700802) ; Inter governmental cooperation in science and technology(2016YFE0125300) ; NSFC(81172182 ; National Natural Science Foundation of China(81227901) ; 81671829)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000426154500018
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21953
Collection中国科学院分子影像重点实验室
Affiliation1.Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
2.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore
Recommended Citation
GB/T 7714
Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(9).
APA Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Jingyun.,...&Feng, Si-Shen.(2018)."All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration.ADVANCED FUNCTIONAL MATERIALS,28(9).
MLA Yan, Hao,et al.""All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration".ADVANCED FUNCTIONAL MATERIALS 28.9(2018).
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