Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration | |
Yan, Hao1,2; Shang, Wenting3 ; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Jingyun1; Xiong, Zhiyuan1; Yuan, Jie1; Zhang, Ranran1; Huang, Qianli1; Wang, Kun3; Li, Baohua2; Tian, Jie3; Kang, Feiyu1,2; Feng, Si-Shen4
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| Source Publication | ADVANCED FUNCTIONAL MATERIALS
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| 2018-02-28 | |
| Volume | 28Issue:9 |
| Subtype | Article |
| Abstract | Great efforts have been devoted so far to combine nano-magnetic hyperthermia and nano-photothermal therapy to achieve encouraging additive therapeutic performance in vitro and in vivo with limitation to direct intratumoral injection and no guidance of multimodality molecular imaging. In this study, a novel multifunctional theranostic nanoplatform (MNP@PES-Cy7/2-DG) consisting of magnetic nanoparticles (MNPs), poly(3,4-ethylenedioxythiophene): poly(4-styre-nesulfonate) (PES), Cyanine7 (Cy7), and 2-deoxyglucose (2-DG)-polyethylene glycol is developed. They are then applied to combined photo-magnetic hyperthermia therapy under intravenous administration that is simultaneously guided by trimodality molecular imaging. Remarkably, nanoparticles are found aggregated mainly in the cytoplasm of tumor cells in vitro and in vivo, and exhibit stealth-like behavior with a long second-phase blood circulation half-life of 20.38 +/- 4.18 h. Under the guidance of photoacoustic/near-infrared fluorescence/magnetic resonance trimodality imaging, tumors can be completely eliminated under intracellular photo-magnetic hyperthermia therapy with additive therapeutic effect due to precise hyperthermia. This study may promote a further exploration of such a platform for clinical applications. |
| Keyword | Breast Cancer Hyperthermia Molecular Imaging Nanomedicine Nanotheranostics |
| WOS Headings | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.1002/adfm.201705710 |
| WOS Keyword | IRON-OXIDE NANOPARTICLES ; PHOTOTHERMAL THERAPY ; PROSTATE-CANCER ; POLYPYRROLE NANOPARTICLES ; COMBINATION THERAPY ; DRUG CARRIER ; THERMOTHERAPY ; FEASIBILITY ; NANOCOMPOSITES ; EFFICIENCY |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Key Research and Development Program of China(2016YFB0700802) ; Inter governmental cooperation in science and technology(2016YFE0125300) ; NSFC(81172182 ; National Natural Science Foundation of China(81227901) ; 81671829) |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS ID | WOS:000426154500018 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/21953 |
| Collection | 中国科学院分子影像重点实验室 |
| Affiliation | 1.Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing 100084, Peoples R China 2.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore |
| Recommended Citation GB/T 7714 | Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(9). |
| APA | Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Jingyun.,...&Feng, Si-Shen.(2018)."All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration.ADVANCED FUNCTIONAL MATERIALS,28(9). |
| MLA | Yan, Hao,et al.""All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration".ADVANCED FUNCTIONAL MATERIALS 28.9(2018). |
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| 14.Hao Yan.pdf（5365KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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