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Altered interhemispheric resting-state functional connectivity in young male smokers
Yu, Dahua1; Yuan, Kai1,2; Bi, Yanzhi2; Luo, Lin3; Zhai, Jinquan3; Liu, Bo3; Li, Yangding4; Cheng, Jiadong2; Guan, Yanyan2; Xue, Ting1; Bu, Limei1; Su, Shaoping1; Ma, Yao1; Qin, Wei2; Tian, Jie2,5; Lu, Xiaoqi1
2018-03-01
发表期刊ADDICTION BIOLOGY
卷号23期号:2页码:772-780
文章类型Article
摘要With the help of advanced neuroimaging approaches, previous studies revealed structural and functional brain changes in smokers compared with healthy non-smokers. Homotopic resting-state functional connectivity between the corresponding regions in cerebral hemispheres may help us to deduce the changes of functional coordination in the whole brain of young male smokers. Functional homotopy reflects an essential aspect of brain function and communication between the left and right cerebral hemispheres, which is important for the integrity of brain function. However, few studies used voxel mirrored homotopic connectivity (VMHC) method to investigate the changes of homotopic connectivity in young male smokers. Twenty-seven young male smokers and 27 matched healthy male non-smokers were recruited in our study. Compared with healthy male non-smokers, young male smokers showed decreased VMHC values in the insula and putamen, and increased VMHC values in the prefrontal cortex. Correlation analysis demonstrated that there were significant positive correlations between the average VMHC values of the prefrontal cortex and pack-years in young male smokers. In addition, significant negative correlation was found between the average VMHC values in the insula and pack-years. Our results revealed the disrupted homotopic resting-state functional connectivity in young male smokers. The novel findings may extend our understanding of smoking.
关键词Resting State Smoking Voxel Mirrored Homotopic Connectivity (Vmhc)
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1111/adb.12515
关键词[WOS]ADOLESCENT NICOTINE EXPOSURE ; WHITE-MATTER MICROSTRUCTURE ; PREFRONTAL CORTEX ; CORPUS-CALLOSUM ; CIGARETTE-SMOKING ; ORBITOFRONTAL CORTEX ; REGIONAL HOMOGENEITY ; BRAIN NETWORKS ; TOBACCO-SMOKE ; ADDICTION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571753 ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610 ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; General Financial Grant the China Post-doctoral Science Foundation(2014 M552416) ; 81571751 ; JB121405) ; 2015MS0604) ; 2014QDL002) ; 81301281 ; 81401488 ; 61179019 ; 81401478 ; 81271644 ; 81271546 ; 81271549 ; 81470816 ; 81471737)
WOS研究方向Biochemistry & Molecular Biology ; Substance Abuse
WOS类目Biochemistry & Molecular Biology ; Substance Abuse
WOS记录号WOS:000425369000021
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21962
专题中国科学院分子影像重点实验室
作者单位1.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Baotou Med Coll, Dept Med Imaging, Affiliated Hosp 1, Baotou, Peoples R China
4.Guangxi Normal Univ, Guangxi Key Lab Multisource Informat Min & Secur, Guilin, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
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GB/T 7714
Yu, Dahua,Yuan, Kai,Bi, Yanzhi,et al. Altered interhemispheric resting-state functional connectivity in young male smokers[J]. ADDICTION BIOLOGY,2018,23(2):772-780.
APA Yu, Dahua.,Yuan, Kai.,Bi, Yanzhi.,Luo, Lin.,Zhai, Jinquan.,...&Lu, Xiaoqi.(2018).Altered interhemispheric resting-state functional connectivity in young male smokers.ADDICTION BIOLOGY,23(2),772-780.
MLA Yu, Dahua,et al."Altered interhemispheric resting-state functional connectivity in young male smokers".ADDICTION BIOLOGY 23.2(2018):772-780.
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