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The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles
Li, Yunfang1; Shang, Wenting2; Liang, Xiaoyuan2; Zeng, Chaoting2; Liu, Mingming1; Wang, Sudan1; Li, Hongjun1; Tian, Jie2
2018
发表期刊RSC ADVANCES
卷号8期号:12页码:6699-6708
文章类型Article
摘要Hepatic fibrosis (HF), as the only reversible process of chronic liver disease, remains a big diagnostic challenge. Development of noninvasive and effective methods to assess quantitatively early-stage HF is of great clinical importance. Compared with conventional diagnostic methods, near-infrared fluorescence imaging (NIR) and magnetic resonance imaging (MRI) could offer highly sensitive and spatial resolution signals for HF detection. However, precise detection using contrast agents is not possible. Superparamagnetic iron oxide (SPIO) nanoparticles have low toxicity, high sensitivity and excellent biocompatibility. Integration of Fe3O4 nanoparticles and indocyanine green (ICG), coupled with targeting ligand of integrin alpha(v)beta(3), arginine-glycine-aspartic acid (RGD) expressed on hepatic stellate cells (HSCs), were used to detect HF. Both in vivo and in vitro results showed that the SPIO@SiO2-ICG-RGD had high stability and low cytotoxicity. The biodistribution of SPIO@SiO2-ICG-RGD was significantly different between mice with HF and healthy controls. SPIO@SiO2-ICG-RGD was characterized and the results of imaging in vitro and in vivo demonstrated the expression of integrin alpha(v)beta(3) on activated HSCs. These data suggest that our SPIO@SiO(2)ICG- RGD probe could be used for the diagnosis of early-stage HF. This new nanoprobe with a dualmodality imaging approach holds great potential for the diagnosis and classification of HF.
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c7ra10847h
关键词[WOS]INTEGRIN ALPHA-V-BETA-3 EXPRESSION ; LIVER FIBROSIS ; STELLATE CELLS ; INJURY ; APOPTOSIS ; RECEPTOR ; LIGAND ; OXIDE ; RAT ; MRI
收录类别SCI
语种英语
项目资助者Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201511) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(XDB02060010) ; 81501540)
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000425034000061
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21972
专题中国科学院分子影像重点实验室
作者单位1.Capital Med Univ, Beijing YouAn Hosp, Dept Radiol, 8 Xitoutiao, Beijing 100069, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
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Li, Yunfang,Shang, Wenting,Liang, Xiaoyuan,et al. The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles[J]. RSC ADVANCES,2018,8(12):6699-6708.
APA Li, Yunfang.,Shang, Wenting.,Liang, Xiaoyuan.,Zeng, Chaoting.,Liu, Mingming.,...&Tian, Jie.(2018).The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles.RSC ADVANCES,8(12),6699-6708.
MLA Li, Yunfang,et al."The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dual-modality nanoparticles".RSC ADVANCES 8.12(2018):6699-6708.
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