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Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects
Liu, Shuai1; Wang, Yinyan1; Xu, Kaibin2,3,4; Ping, Fan5,6; Li, Fang6,7; Wang, Renzhi6,8; Cheng, Xin6,7
Source PublicationNEUROIMAGE-CLINICAL
2018
Volume17Pages:354-358
SubtypeArticle
AbstractCognitive impairment and psychiatric symptoms are common in patients with Cushing's disease (CD) owing to elevated levels of glucocorticoids. Molecular neuroimaging methods may help to detect changes in the brain of patients with CD. The aim of this study was to investigate the characteristics of brain metabolism and its association with serum cortisol level in CD. We compared brain metabolism, as measured using [F-18]-fluorodeoxyglucose positron emission tomography (FDG PET), between 92 patients with CD and 118 normal subjects on a voxel-wise basis. Pearson correlation was performed to evaluate the association between cerebral FDG uptake and serum cortisol level in patients with CD. We demonstrated that certain brain regions in patients with CD showed significantly increased FDG uptake, including the basal ganglia, anteromedial temporal lobe, thalamus, precentral cortex, and cerebellum. The clusters that demonstrated significantly decreased uptake were mainly located in the medial and lateral frontal cortex, superior and inferior parietal lobule, medial occipital cortex, and insular cortex. The metabolic rate of the majority of these regions was found to be significantly correlated with the serum cortisol level. Our findings may help to explain the underlying mechanisms of cognitive impairment and psychiatric symptoms in patients exposed to excessive glucocorticoids and evaluate the efficacy of treatments during follow-up.
KeywordCushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.10.038
WOS KeywordPITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; LONG-TERM REMISSION ; QUALITY-OF-LIFE ; CORTISOL-LEVELS ; LIMBIC SYSTEM ; STRESS ; VOLUME ; HIPPOCAMPUS ; IMPROVEMENT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81201121) ; Beijing Postdoctoral Research Foundation(2017-ZZ-116)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000426180300038
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21973
Collection脑网络组研究中心
Affiliation1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Peking Union Med Coll, Beijing 100730, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
8.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects[J]. NEUROIMAGE-CLINICAL,2018,17:354-358.
APA Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Li, Fang.,...&Cheng, Xin.(2018).Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects.NEUROIMAGE-CLINICAL,17,354-358.
MLA Liu, Shuai,et al."Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects".NEUROIMAGE-CLINICAL 17(2018):354-358.
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