Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects

doi:10.1016/j.nicl.2017.10.038

	Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects
	Liu, Shuai 1; Wang, Yinyan 1; Xu, Kaibin2,3,4 ; Ping, Fan 5,6; Li, Fang 6,7; Wang, Renzhi 6,8; Cheng, Xin 6,7
发表期刊	NEUROIMAGE-CLINICAL
	2018
卷号	17 页码:354-358
文章类型	Article
摘要	Cognitive impairment and psychiatric symptoms are common in patients with Cushing's disease (CD) owing to elevated levels of glucocorticoids. Molecular neuroimaging methods may help to detect changes in the brain of patients with CD. The aim of this study was to investigate the characteristics of brain metabolism and its association with serum cortisol level in CD. We compared brain metabolism, as measured using [F-18]-fluorodeoxyglucose positron emission tomography (FDG PET), between 92 patients with CD and 118 normal subjects on a voxel-wise basis. Pearson correlation was performed to evaluate the association between cerebral FDG uptake and serum cortisol level in patients with CD. We demonstrated that certain brain regions in patients with CD showed significantly increased FDG uptake, including the basal ganglia, anteromedial temporal lobe, thalamus, precentral cortex, and cerebellum. The clusters that demonstrated significantly decreased uptake were mainly located in the medial and lateral frontal cortex, superior and inferior parietal lobule, medial occipital cortex, and insular cortex. The metabolic rate of the majority of these regions was found to be significantly correlated with the serum cortisol level. Our findings may help to explain the underlying mechanisms of cognitive impairment and psychiatric symptoms in patients exposed to excessive glucocorticoids and evaluate the efficacy of treatments during follow-up.
关键词	Cushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.nicl.2017.10.038
关键词[WOS]	PITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; LONG-TERM REMISSION ; QUALITY-OF-LIFE ; CORTISOL-LEVELS ; LIMBIC SYSTEM ; STRESS ; VOLUME ; HIPPOCAMPUS ; IMPROVEMENT
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81201121) ; Beijing Postdoctoral Research Foundation(2017-ZZ-116)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000426180300038
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21973
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China 6.Peking Union Med Coll, Beijing 100730, Peoples R China 7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China 8.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects[J]. NEUROIMAGE-CLINICAL,2018,17:354-358.
APA	Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Li, Fang.,...&Cheng, Xin.(2018).Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects.NEUROIMAGE-CLINICAL,17,354-358.
MLA	Liu, Shuai,et al."Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects".NEUROIMAGE-CLINICAL 17(2018):354-358.