CASIA OpenIR  > 脑网络组研究中心
Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults
Xu, Qiang1; Fu, Jilian1; Liu, Feng1; Qin, Wen1; Liu, Bing2; Jiang, Tianzi2; Yu, Chunshui1
2018-04-10
发表期刊FRONTIERS IN NEUROSCIENCE
卷号12
文章类型Article
摘要In Chinese Han population, Catechol-O-methyltransferase gene (COMT) rs4633 is found to be associated with impaired cognitive process. We aimed to investigate the association between COMT rs4633 and verbal intelligence and the underlying neural mechanisms in Chinese Han healthy young adults. In 256 Chinese Han healthy young adults, we explored the modulatory effects of COMT rs4633 on verbal intelligence quotient (VIQ) and functional connectivity density (FCD) of the brain and the mediation effect of FCD on the association between COMT and VIQ. We further investigated the association between the expression patterns of dopamine receptor genes and the effect of COMT on FCD in the human brain. COMT rs4633 TT homozygotes exhibited lower VIQ than CC homozygotes and TC heterozygotes, higher long-range FCD (IrFCD) than CC homozygotes and TO heterozygotes in the left superior frontal gyrus. TT homozygotes and TC heterozygotes showed higher IrFCD than CC homozygotes in the left inferior parietal lobule. The IrFCD differences across genotypic subgroups were negatively associated with the expression of DRD2 and DRD3 genes. The left parietal IrFCD mediated the association between COMT rs4633 and VIQ. These findings provide a biological pathway that COMT rs4633 affects verbal intelligence via modulating the IrFCD of the left inferior parietal lobule.
关键词Comt Functional Connectivity Density Functional Magnetic Resonance Imaging Single Nucleotide Polymorphism Verbal Intelligence
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnins.2018.00233
关键词[WOS]CATECHOL-O-METHYLTRANSFERASE ; HUMAN BRAIN ; WORKING-MEMORY ; DOPAMINE ; SCHIZOPHRENIA ; DENSITY ; EXPRESSION ; RECEPTORS ; NETWORKS ; PLASMA
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China(81425013 ; 81501451 ; 81401394)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000429597100001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22010
专题脑网络组研究中心
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xu, Qiang,Fu, Jilian,Liu, Feng,et al. Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults[J]. FRONTIERS IN NEUROSCIENCE,2018,12.
APA Xu, Qiang.,Fu, Jilian.,Liu, Feng.,Qin, Wen.,Liu, Bing.,...&Yu, Chunshui.(2018).Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults.FRONTIERS IN NEUROSCIENCE,12.
MLA Xu, Qiang,et al."Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults".FRONTIERS IN NEUROSCIENCE 12(2018).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Qiang]的文章
[Fu, Jilian]的文章
[Liu, Feng]的文章
百度学术
百度学术中相似的文章
[Xu, Qiang]的文章
[Fu, Jilian]的文章
[Liu, Feng]的文章
必应学术
必应学术中相似的文章
[Xu, Qiang]的文章
[Fu, Jilian]的文章
[Liu, Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。