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Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults
Xu, Qiang1; Fu, Jilian1; Liu, Feng1; Qin, Wen1; Liu, Bing2; Jiang, Tianzi2; Yu, Chunshui1
Source PublicationFRONTIERS IN NEUROSCIENCE
2018-04-10
Volume12
SubtypeArticle
AbstractIn Chinese Han population, Catechol-O-methyltransferase gene (COMT) rs4633 is found to be associated with impaired cognitive process. We aimed to investigate the association between COMT rs4633 and verbal intelligence and the underlying neural mechanisms in Chinese Han healthy young adults. In 256 Chinese Han healthy young adults, we explored the modulatory effects of COMT rs4633 on verbal intelligence quotient (VIQ) and functional connectivity density (FCD) of the brain and the mediation effect of FCD on the association between COMT and VIQ. We further investigated the association between the expression patterns of dopamine receptor genes and the effect of COMT on FCD in the human brain. COMT rs4633 TT homozygotes exhibited lower VIQ than CC homozygotes and TC heterozygotes, higher long-range FCD (IrFCD) than CC homozygotes and TO heterozygotes in the left superior frontal gyrus. TT homozygotes and TC heterozygotes showed higher IrFCD than CC homozygotes in the left inferior parietal lobule. The IrFCD differences across genotypic subgroups were negatively associated with the expression of DRD2 and DRD3 genes. The left parietal IrFCD mediated the association between COMT rs4633 and VIQ. These findings provide a biological pathway that COMT rs4633 affects verbal intelligence via modulating the IrFCD of the left inferior parietal lobule.
KeywordComt Functional Connectivity Density Functional Magnetic Resonance Imaging Single Nucleotide Polymorphism Verbal Intelligence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnins.2018.00233
WOS KeywordCATECHOL-O-METHYLTRANSFERASE ; HUMAN BRAIN ; WORKING-MEMORY ; DOPAMINE ; SCHIZOPHRENIA ; DENSITY ; EXPRESSION ; RECEPTORS ; NETWORKS ; PLASMA
Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China(81425013 ; 81501451 ; 81401394)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000429597100001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22010
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qiang,Fu, Jilian,Liu, Feng,et al. Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults[J]. FRONTIERS IN NEUROSCIENCE,2018,12.
APA Xu, Qiang.,Fu, Jilian.,Liu, Feng.,Qin, Wen.,Liu, Bing.,...&Yu, Chunshui.(2018).Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults.FRONTIERS IN NEUROSCIENCE,12.
MLA Xu, Qiang,et al."Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults".FRONTIERS IN NEUROSCIENCE 12(2018).
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