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Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory
Wang, Chao1,2; Liu, Bing3,4; Zhang, Xiaolong3,4; Cui, Yue3,4; Yu, Chunshui6; Jiang, Tianzi2,3,4,5,7
2018-03-29
发表期刊SCIENTIFIC REPORTS
卷号8
文章类型Article
摘要Dopamine is critical in pathophysiology and therapy of schizophrenia. Many studies have reported altered dopaminergic activity in the dorsal but not ventral striatum in schizophrenia. Based on the largest genome-wide association study of schizophrenia to date, we calculated the polygenic risk score (PGRS) of each subject in a healthy general group, including all variations in the set of functionally related genes involved in dopamine neurotransmitter system. We aimed to test whether the genetic variations in the dopaminergic pathway that have been identified as associated with schizophrenia are related to the function of the striatum and to working memory. We found that a higher PGRS was significantly associated with impairment in working memory. Moreover, resting-state functional connectivity analysis revealed that as the polygenic risk score increased, the connections between left putamen and caudate and the default mode network grew stronger, while the connections with the fronto-parietal network grew weaker. Our findings may shed light on the biological mechanism underlying the "dopamine hypothesis" of schizophrenia and provide some implications regarding the polygenic effects on the dopaminergic activity in the risk for schizophrenia.
WOS标题词Science & Technology
DOI10.1038/s41598-018-23191-y
关键词[WOS]DORSOLATERAL PREFRONTAL CORTEX ; GENOME-WIDE ASSOCIATION ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; RISK LOCI ; SCHIZOPHRENIA ; RECEPTORS ; STATE ; ABNORMALITIES ; INEFFICIENCY
收录类别SCI ; SSCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31600920 ; Beijing Nova Program(2010B06) ; Natural Science Foundation of SZU(2016071) ; 91232718 ; 91132301)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000428618900015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22013
专题脑网络组研究中心
作者单位1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China
6.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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Wang, Chao,Liu, Bing,Zhang, Xiaolong,et al. Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory[J]. SCIENTIFIC REPORTS,2018,8.
APA Wang, Chao,Liu, Bing,Zhang, Xiaolong,Cui, Yue,Yu, Chunshui,&Jiang, Tianzi.(2018).Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory.SCIENTIFIC REPORTS,8.
MLA Wang, Chao,et al."Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory".SCIENTIFIC REPORTS 8(2018).
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