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Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer
Sun, Mengmeng1; Guo, Jianwen1; Hao, Hanjun1; Tong, Tong2; Wang, Kun2; Gao, Weiping1
2018
发表期刊THERANOSTICS
卷号8期号:10页码:2634-2645
文章类型Article
摘要Near-infrared (NIR)-absorbing conjugated polymer nanoparticles are interesting for imaging-guided combination therapy, especially for synergistic photothermal therapy and chemotherapy; however, most of them target tumours passively through the enhanced permeability and retention (EPR) effect, leading to low utilization efficiency. To address this problem, we report an active tumour-targeting strategy of tumour-homing chimeric polypeptide-conjugated NIR-absorbing conjugated-polymer nanoparticles as a new class of drug nanocarriers for imaging-guided combination therapy of cancer.
关键词Tumour Targeting Nanomedicine Polypyrrole Photothermal Therapy Combination Therapy
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.24705
关键词[WOS]IN-VIVO ; DOXORUBICIN CONJUGATE ; DRUG CARRIER ; POLYMERS ; DELIVERY ; AGENTS ; CELLS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(21534006) ; Beijing Natural Science Foundation(2172028)
WOS研究方向Research & Experimental Medicine
WOS类目Medicine, Research & Experimental
WOS记录号WOS:000429878500003
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22015
专题中国科学院分子影像重点实验室
作者单位1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Sun, Mengmeng,Guo, Jianwen,Hao, Hanjun,et al. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer[J]. THERANOSTICS,2018,8(10):2634-2645.
APA Sun, Mengmeng,Guo, Jianwen,Hao, Hanjun,Tong, Tong,Wang, Kun,&Gao, Weiping.(2018).Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer.THERANOSTICS,8(10),2634-2645.
MLA Sun, Mengmeng,et al."Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer".THERANOSTICS 8.10(2018):2634-2645.
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