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The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
Genon, Sarah1; Reid, Andrew7; Li, Hai5,6; Fan, Lingzhong5,6; Mueller, Veronika I.1,3; Cieslik, Edna C.1,3; Hoffstaedter, Felix1; Langner, Robert1,3; Grefkesh, Christian2,4; Laird, Angela R.8; Fox, Peter T.9; Jiang, Tianzi5,6; Annunts, Katrin1,10; Eickhoff, Simon B.1,3
Source PublicationNEUROIMAGE
2018-04-15
Volume170Pages:400-411
SubtypeArticle
AbstractDespite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd.
KeywordPrecentral Gyrus Eye-field Meta-analytic Connectivity Modeling Probabilistic Diffusion Tractography Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroimage.2017.02.034
WOS KeywordACTIVATION-BASED PARCELLATION ; PRIMARY MOTOR CORTEX ; ROSTRO-CAUDAL AXIS ; INTERINDIVIDUAL VARIABILITY ; MACAQUE MONKEY ; HUMAN BRAIN ; PARIETAL CORTEX ; FRONTAL-CORTEX ; AREAS ; METAANALYSIS
Indexed BySCI
Language英语
Funding OrganizationDeutsche Forschungsgemeinschaft (DFG)(EI 816/4-1 ; National Institute of Mental Health(R01-MH074457) ; Helmholtz Portfolio Theme "Supercomputing and Modelling for the Human Brain" ; European Union(7202070) ; LA 3071/3-1 ; GE 2835/1-1)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000429940900032
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22018
Collection脑网络组研究中心
Affiliation1.Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany
2.Res Ctr Julich, Inst Neurosci & Med INM 3, Julich, Germany
3.Heinrich Heine Univ Dusseldorf, Fac Med, Inst Syst Neurosci, Dusseldorf, Germany
4.Cologne Univ Hosp, Dept Neurol, Cologne, Germany
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
7.Radboud Univ Nijmegen, Donders Ctr Cognit, Dept Artificial Intelligence, Nijmegen, Netherlands
8.Neuroinformat & Brain Connect Lab, Miami, FL USA
9.Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA
10.Heinrich Heine Univ Dusseldorf, C & O Vogt Inst Brain Res, Dusseldorf, Germany
Recommended Citation
GB/T 7714
Genon, Sarah,Reid, Andrew,Li, Hai,et al. The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization[J]. NEUROIMAGE,2018,170:400-411.
APA Genon, Sarah.,Reid, Andrew.,Li, Hai.,Fan, Lingzhong.,Mueller, Veronika I..,...&Eickhoff, Simon B..(2018).The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization.NEUROIMAGE,170,400-411.
MLA Genon, Sarah,et al."The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization".NEUROIMAGE 170(2018):400-411.
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