CASIA OpenIR  > 中国科学院分子影像重点实验室
Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy
Li, Juan1,2; Du, Yang3; Jiang, Zhenqi1,2,4; Tian, Yuchen1,2; Qiu, Nianxiang1,2; Wang, Yinjie1,2,4; Lqbal, Muhammad Zubair1,2; Hu, Menying1,2; Zou, Ruifen1,2,4; Luo, Lijia1,2,4; Du, Shiyu1,2; Tian, Jie3; Wu, Aiguo1,2
Source PublicationNANOSCALE
2018-04-07
Volume10Issue:13Pages:5845-5851
SubtypeArticle
AbstractDue to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y-1 receptors (Y(1)Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn(6), Pro(34)] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y(1)Rs are over expressed.
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c8nr00148k
WOS KeywordBLOOD-BRAIN-BARRIER ; NEUROPEPTIDE-Y RECEPTORS ; BREAST-CANCER ; TUMOR HETEROGENEITY ; DRUG-DELIVERY ; HIGH-GRADE ; NANOPARTICLES ; INTERNALIZATION ; Y-1-RECEPTOR ; PERMEABILITY
Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China(51303196 ; Science and Technology Department of Zhejiang Province(2016C33093 ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase)(U1501501) ; Youth Innovation Promotion Association Foundation, CAS(2017340) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Bureau of Science and Technology of Ningbo Municipality City(2015C50004 ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; U1432114 ; 2017C33129 ; 2015B11002 ; 81227901 ; 2017C03042 ; 2017C110022) ; 81527805 ; LY18H180011) ; 61231004 ; 81470083)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000428788200007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22020
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Zhejiang, Peoples R China
2.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, Ningbo 315201, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Automat, Sate Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Juan,Du, Yang,Jiang, Zhenqi,et al. Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy[J]. NANOSCALE,2018,10(13):5845-5851.
APA Li, Juan.,Du, Yang.,Jiang, Zhenqi.,Tian, Yuchen.,Qiu, Nianxiang.,...&Wu, Aiguo.(2018).Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy.NANOSCALE,10(13),5845-5851.
MLA Li, Juan,et al."Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy".NANOSCALE 10.13(2018):5845-5851.
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