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Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery
Ai, Ting1,2,4; Shang, Wenting2; Yan, Hao2; Zeng, Chaoting2; Wang, Kun2,3; Gao, Yuan2; Guan, Tianpei1,2,4; Fang, Chihua1,4; Tian, Jie2,3
2018-06-01
发表期刊BIOMATERIALS
卷号167期号:167页码:216-225
文章类型Article
摘要Hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, is increasing nowadays and poses a serious threat to human health. However, if treated effectively and timely, it is clinically manageable or curable. Therefore, accurate detection and complete surgical resection remain priorities for HCC with a high potential of improving both survival and quality of life. Lacking of real-time guide technology, traditional surgery are usually relied on the subjective experience of surgeon, which have the limitation of high sensitivity detection tumor. Here, we developed a contrast agent, ZnGa2O4Cr0.004 (ZGC), used for guided surgery during operation to accurate delineation of HCC. ZGC showed excellent long-lasting afterglow properties that lasted for hours, which can aid in real-time guided surgery. Meanwhile, ZGC display high spatial resolution and deep penetration during pre-operation for diagnostic computed tomography (CT). Interestingly, we observed reverse imaging in the tumor region, known as a "dark hole", which further improves the contrast for surgery. This new multi-modality nanoparticle has great potential for accurate liver cancer imaging and resection guidance. (C) 2018 Published by Elsevier Ltd.
关键词Hepatocellular Carcinoma Persistent Luminescent Nanoparticles Preoperative Diagnosis Luminescence-guided Surgery
WOS标题词Science & Technology ; Technology
DOI10.1016/j.biomaterials.2018.01.031
关键词[WOS]PHOTODYNAMIC THERAPY ; QUANTUM DOTS ; CELLS ; FLUORESCENCE ; NANOPROBES ; ZINC ; PHOTOSENSITIZER ; DIAGNOSTICS ; ONCOLOGY ; GALLIUM
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81627805 ; National Key Research and Development Program of China(2016YFC0106500 ; United Fund of National Natural Science Foundation of China and Government of Guangdong Province(U1401254) ; Science and Technology Plan Project of Guangdong Province(2016A020220013) ; Science and Technology Plan Project of Guangzhou(201604020144 ; 81601576 ; 2017YFA0205200 ; 201704020141) ; 81227901 ; 2016YFA0201401 ; 61231004 ; 2016YFC0102601) ; 81501540 ; 61671449 ; 81401471 ; 81527805)
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000430899200018
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22023
专题中国科学院分子影像重点实验室
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, 253 Gongye Ave, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Guang Dong Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Guangdong, Peoples R China
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GB/T 7714
Ai, Ting,Shang, Wenting,Yan, Hao,et al. Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery[J]. BIOMATERIALS,2018,167(167):216-225.
APA Ai, Ting.,Shang, Wenting.,Yan, Hao.,Zeng, Chaoting.,Wang, Kun.,...&Tian, Jie.(2018).Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery.BIOMATERIALS,167(167),216-225.
MLA Ai, Ting,et al."Near infrared-emitting persistent luminescent nanoparticles for Hepatocellular Carcinoma imaging and luminescence-guided surgery".BIOMATERIALS 167.167(2018):216-225.
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