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An Innovation for Treating Orthotopic Pancreatic Cancer by Preoperative Screening and Imaging-Guided Surgery
Ziyu Han1,2,3,4; Wenting Shang2; Xiaoyuan Liang1,4; Hao Yan2; Min Hu1,4; Li Peng2; Hongmei Jiang2; Chihua Fang1,4; Jie Tian2,3,5,6
2018-06
发表期刊Molecular Imaging And Biology
期号x页码:x
摘要Purpose: Pancreatic cancer is still associated with a poor outcome and low patient quality of life,
which are mainly attributed to the late detection and requirement of distal pancreatectomy with
extended resection of pancreatic tumors. Therefore, novel strategies for early screening and
precise tumor resection are urgently needed. In this study, we evaluated the feasibility of a lowdensity lipoprotein receptor (LDLR)-targeted small-molecule contrast agent (peptide-22-Cy7) for
early screening with photoacoustic tomography and near-infrared (NIR) imaging as guided
surgical navigation to achieve precise resection.

Procedure: Normal pancreatic cells (HPDE6-C7) and cancer cells (PANC-1) were respectively
used in the
in vitro targeting evaluations. The ability of peptide-22-Cy7 for preoperative in vivo
pancreatic tumor detection was investigated in a mouse orthotopic pancreatic cancer model (n =
10) using photoacoustic tomography; 18 tumor-bearing mice were further divided into three
groups for different treatments. After intravenous injection of peptide-22-Cy7, surgical navigation
was conducted through laparotomy. Histopathological analysis was used to further confirm the
tumor area and the state of surgical margins.

Results: Flow cytometry demonstrated that peptide-22 is highly specific to pancreatic cancer
cells, with a fluorescence intensity of approximately 87.3 %. Orthotopic pancreatic tumors with a
size of 4 mm could be accurately detected by photoacoustic tomography. Surgical navigation
effectively achieved R0 resection and minimized the range of resection, which led to increased
body weight of the mice following surgery.

关键词Low-density Lipoprotein Receptor (Ldlr) Photoacoustic Imaging Peptide-22 Optical-guided Surgery
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22025
专题中国科学院分子影像重点实验室
作者单位1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China
2.CAS Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China
3.University of Chinese Academy of Sciences, Beijing, 100080, China 4
4.Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, 510280, China
5.CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China
6.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road #95, Haidian Dist, Beijing, 100190, China
推荐引用方式
GB/T 7714
Ziyu Han,Wenting Shang,Xiaoyuan Liang,et al. An Innovation for Treating Orthotopic Pancreatic Cancer by Preoperative Screening and Imaging-Guided Surgery[J]. Molecular Imaging And Biology,2018(x):x.
APA Ziyu Han.,Wenting Shang.,Xiaoyuan Liang.,Hao Yan.,Min Hu.,...&Jie Tian.(2018).An Innovation for Treating Orthotopic Pancreatic Cancer by Preoperative Screening and Imaging-Guided Surgery.Molecular Imaging And Biology(x),x.
MLA Ziyu Han,et al."An Innovation for Treating Orthotopic Pancreatic Cancer by Preoperative Screening and Imaging-Guided Surgery".Molecular Imaging And Biology .x(2018):x.
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