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Advanced nanomaterials targeting hypoxia to enhance radiotherapy
Jia Li; Wenting Shang; Yong Li; Sirui Fu; Jie Tian; Ligong Lu
2018-09
发表期刊International Journal of Nanomedicine
期号13页码:5925-5936
摘要Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The
development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-
Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively
triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the feld of nanomedicine focused on tumor hypoxia to improve clinical outcomes

关键词Radiotherapy Hypoxia Nanomaterials Hypoxia-inducible Factor
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22028
专题中国科学院分子影像重点实验室
作者单位1.Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
3.Beijing Key Laboratory of Molecular Imaging, Beijing, China
推荐引用方式
GB/T 7714
Jia Li,Wenting Shang,Yong Li,et al. Advanced nanomaterials targeting hypoxia to enhance radiotherapy[J]. International Journal of Nanomedicine,2018(13):5925-5936.
APA Jia Li,Wenting Shang,Yong Li,Sirui Fu,Jie Tian,&Ligong Lu.(2018).Advanced nanomaterials targeting hypoxia to enhance radiotherapy.International Journal of Nanomedicine(13),5925-5936.
MLA Jia Li,et al."Advanced nanomaterials targeting hypoxia to enhance radiotherapy".International Journal of Nanomedicine .13(2018):5925-5936.
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