The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dualmodality nanoparticles

	The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dualmodality nanoparticles
	Yunfang Li 1; Wenting Shang2 ; Xiaoyuan Liang 2; Chaoting Zeng 2; Mingming Liu 1; Sudan Wang 1; Hongjun Li 1; Jie Tian 2
发表期刊	RSC Advances
	2018-02
期号	8 页码:6699
摘要	Hepatic fibrosis (HF), as the only reversible process of chronic liver disease, remains a big diagnostic challenge. Development of noninvasive and effective methods to assess quantitatively early-stage HF is of great clinical importance. Compared with conventional diagnostic methods, near-infrared fluorescence imaging (NIR) and magnetic resonance imaging (MRI) could offer highly sensitive and spatial resolution signals for HF detection. However, precise detection using contrast agents is not possible. Superparamagnetic iron oxide (SPIO) nanoparticles have low toxicity, high sensitivity and excellent biocompatibility. Integration of Fe3O4 nanoparticles and indocyanine green (ICG), coupled with targeting ligand of integrin avb3, arginine– glycine–aspartic acid (RGD) expressed on hepatic stellate cells (HSCs), were used to detect HF. Both in vivo and in vitro results showed that the SPIO@SiO2–ICG–RGD had high stability and low cytotoxicity. The biodistribution of SPIO@SiO2–ICG–RGD was significantly different between mice with HF and healthy controls. SPIO@SiO2–ICG–RGD was characterized and the results of imaging in vitro and in vivo demonstrated the expression of integrin avb3 on activated HSCs. These data suggest that our SPIO@SiO2– ICG–RGD probe could be used for the diagnosis of early-stage HF. This new nanoprobe with a dualmodality imaging approach holds great potential for the diagnosis and classification of HF.
关键词	Hepatic Fibrosis Spio@sio2– Icg–rgd Diagnosis
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22029
专题	中国科学院分子影像重点实验室
作者单位	1.Department of Radiology, Beijing YouAn Hospital, Capital Medical University, 8 Xitoutiao, Youanmen, Fengtai District, Beijing, China, 100069 2.Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road #95, Haidian Dist, Beijing 100190, P. R. China.
推荐引用方式 GB/T 7714	Yunfang Li,Wenting Shang,Xiaoyuan Liang,et al. The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dualmodality nanoparticles[J]. RSC Advances,2018(8):6699.
APA	Yunfang Li.,Wenting Shang.,Xiaoyuan Liang.,Chaoting Zeng.,Mingming Liu.,...&Jie Tian.(2018).The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dualmodality nanoparticles.RSC Advances(8),6699.
MLA	Yunfang Li,et al."The diagnosis of hepatic fibrosis by magnetic resonance and near-infrared imaging using dualmodality nanoparticles".RSC Advances .8(2018):6699.

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