A Computational Effort towards the Microscale Mouse Brain Connectome from the Mesoscale

	A Computational Effort towards the Microscale Mouse Brain Connectome from the Mesoscale
	Zhang TL(张铁林)1 ; Ceng Y(曾毅)1,2,3 ; Xu B(徐波)1,2,3 ; Tielin Zhang, Yi Zeng
发表期刊	Journal of Integrative Neuroscience
	2017
卷号	16 期号:3 页码:291-306
摘要	The wiring diagram of the mouse brain presents an indispensable foundation for the research on basic and applied neurobiology. It is also essential as a structural foundation for computational simulation of the brain. Different scales of the connectome give us different hints and clues to understand the functions of the nervous system and how they process information. However, compared to the macroscale and most recent mesoscale mouse brain connectome studies, there is no complete whole brain microscale connectome available because of the scalability and accuracy of automatic recognition techniques. Different scales of the connectivity data are comprehensive descriptions of the whole brain at different levels of details. Hence connectivity results from a neighborhood scale may help to predict each other. Here we report a computational approach to bring the mesoscale connectome a step forward towards the microscale from the perspective of neuron, synapse and network motifs distribution by the connectivity data at the mesoscale and some facts from the anatomical experiments at the microscale. These attempts make a step forward towards the efforts of microscale mouse brain connectome given the fact that the detailed microscale connectome results are still far to be produced due to the limitation of current nano-scale 3-D reconstruction techniques. The generated microscale mouse brain will play a key role on the understanding of the behavioral and cognitive processes of the mouse brain. In this paper, the conversion method which could get the approximate number of neurons and synapses in microscale is proposed and tested in sub-regions of Hippocampal Formation (HF), and is generalized to the whole brain. As a step forward towards understanding the microscale connectome, we propose a microscale motif prediction model to generate understanding on the microscale structure of different brain region from network motif perspective. Correlation analysis shows that the predicted motif distribution is very relevant to the real anatomical brain data at microscale.
关键词	Microscale Brain Connectome Reconstruction
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22082
专题	脑图谱与类脑智能实验室_神经计算与脑机交互
通讯作者	Tielin Zhang, Yi Zeng
作者单位	1.Institute of Automation, Chinese Academy of Sciences, Beijing, China 2.Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China 3.University of Chinese Academy of Sciences, Beijing, China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang TL,Ceng Y,Xu B,et al. A Computational Effort towards the Microscale Mouse Brain Connectome from the Mesoscale[J]. Journal of Integrative Neuroscience,2017,16(3):291-306.
APA	Zhang TL,Ceng Y,Xu B,&Tielin Zhang, Yi Zeng.(2017).A Computational Effort towards the Microscale Mouse Brain Connectome from the Mesoscale.Journal of Integrative Neuroscience,16(3),291-306.
MLA	Zhang TL,et al."A Computational Effort towards the Microscale Mouse Brain Connectome from the Mesoscale".Journal of Integrative Neuroscience 16.3(2017):291-306.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
A Computational Appr（892KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载