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EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer
Li, Yuan1,2,3,4; Du, Yang3,5; Liang, Xiaolong2,6; Sun, Ting1,2,3; Xue, Huadan1,2; Tian, Jie3,5; Jin, Zhengyu1,2
发表期刊NANOSCALE
ISSN2040-3364
2018-09-21
卷号10期号:35页码:16738-16749
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Jin, Zhengyu(zhengyu_jin1960@126.com)
摘要Epidermal growth factor receptor (EGFR) is a major target for the treatment of colorectal cancers (CRCs), and programmed death ligand-1(PD-L1) is an attractive target for CRC immunotherapy. Herein, we report the synthesis of porphyrin-containing liposomal nanohybrid cerasomes decorated with cetuximab, an anti-EGFR antibody, and conjugated with IRDye800CW and MRI contrast DOTA-Gd, to enable in vivo tumor detection and photodynamic therapy (PDT). Moreover, PD-L1 was added for adjuvant therapy. The antitumor efficacy of PDT combined with PD-L1 immunotherapy was assessed. EGFR-targeted nanoparticles showed the targeted imaging of tumors. EGFR-targeted PDT combined with PD-L1 immunotherapy was more effective against tumor growth than simultaneous albeit nontargeted nanoparticle delivery with laser irradiation plus PD-L1 immunotherapy. Thus, EGFR-targeted nanoparticles exhibited significant potential toward dual-modality imaging-guided precise PDT, combined with immunotherapy.
DOI10.1039/c8nr05803b
关键词[WOS]TUMOR-INFILTRATING LYMPHOCYTES ; CELL LUNG-CANCER ; PHOTODYNAMIC THERAPY ; BREAST-CANCER ; NANOPARTICLES ; COMBINATION ; CHEMOTHERAPY ; NIVOLUMAB ; EFFICACY
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[81771846] ; Chinese Academy of Sciences[XDB02060010] ; International Innovation Team of CAS[20140491524] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Peking University Third Hospital[BYSY2015023]
项目资助者National Natural Science Foundation of China ; Chinese Academy of Sciences ; International Innovation Team of CAS ; Beijing Municipal Science & Technology Commission ; Peking University Third Hospital
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000448419900041
出版者ROYAL SOC CHEMISTRY
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22579
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie; Jin, Zhengyu
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China
4.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
6.Peking Univ, Dept Ultrasound, Hosp 3, Beijing 100191, Peoples R China
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Li, Yuan,Du, Yang,Liang, Xiaolong,et al. EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer[J]. NANOSCALE,2018,10(35):16738-16749.
APA Li, Yuan.,Du, Yang.,Liang, Xiaolong.,Sun, Ting.,Xue, Huadan.,...&Jin, Zhengyu.(2018).EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer.NANOSCALE,10(35),16738-16749.
MLA Li, Yuan,et al."EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer".NANOSCALE 10.35(2018):16738-16749.
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