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Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention
Chen, Jiayu1; Hutchison, Kent E.1,2; Bryan, Angela D.2; Filbey, Francesca M.3; Calhoun, Vince D.1,4; Claus, Eric D.1; Lin, Dongdong1; Sui, Jing1,5,6; Du, Yuhui1,7; Liu, Jingyu1,4
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
2018-11-15
Volume9Pages:12
Corresponding AuthorChen, Jiayu(jchen@mrn.org)
AbstractAlcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various stimuli including exercise. Thus, it is an intriguing question whether exercise can lead to methylation changes that are opposite to those related to drinking. We herein conducted a comparative study to explore this issue. Three cohorts were profiled for DNA methylation (DNAm), including a longitudinal exercise intervention cohort (53 healthy participants profiled at baseline and after a 12-months exercise intervention), a cross-sectional case-control cohort (81 hazardous drinkers and 81 healthy controls matched in age and sex), and a cross-sectional binge drinking cohort (281 drinkers). We identified 906 methylation sites showing significant DNAm differences between drinkers and controls in the case-control cohort, as well as, associations with drinking behavior in the drinking cohort. In parallel, 341 sites were identified for significant DNAm alterations between baseline and follow-up in the exercise cohort. Thirty-two sites overlapped between these two set of findings, of which 15 sites showed opposite directions of DNAm associations between exercise and drinking. Annotated genes of these 15 sites were enriched in signaling pathways related to synaptic plasticity. In addition, the identified methylation sites significantly associated with impaired control over drinking, suggesting relevance to neural function. Collectively, the current findings provide preliminary evidence that exercise has the potential to partially reverse DNAm differences associated with drinking at some CpG sites, motivating rigorously designed longitudinal studies to better characterize epigenetic effects with respect to prevention and intervention of AUD.
Keywordalcohol exercise methylation impaired control synaptic plasticity
DOI10.3389/fpsyt.2018.00594
WOS KeywordACID AMIDE HYDROLASE ; DNA METHYLATION ; RESPONSE-INHIBITION ; ALZHEIMERS-DISEASE ; PHYSICAL-ACTIVITY ; SYNAPTIC FUNCTION ; IMPAIRED CONTROL ; SKELETAL-MUSCLE ; BETA-CATENIN ; DRUG-USE
Indexed BySCI
Language英语
Funding ProjectNational Institutes of Health[P20GM103472] ; National Institutes of Health[R01EB005846] ; National Institutes of Health[1R01EB006841] ; National Institutes of Health[R01AA012238] ; National Institutes of Health[R01CA109858] ; National Science Foundation EPSCoR grant[1539067]
Funding OrganizationNational Institutes of Health ; National Science Foundation EPSCoR grant
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000450246700001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22621
Collection脑网络组研究中心
Corresponding AuthorChen, Jiayu
Affiliation1.Mind Res Network, Albuquerque, NM USA
2.Univ Colorado Boulder, Dept Psychol & Neurosci, Boulder, CO USA
3.Univ Texas Dallas, Ctr BrainHlth, Sch Behav & Brain Sci, Dallas, TX USA
4.Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
7.Shanxi Univ, Sch Comp Informat Technol, Taiyuan, Shanxi, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jiayu,Hutchison, Kent E.,Bryan, Angela D.,et al. Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention[J]. FRONTIERS IN PSYCHIATRY,2018,9:12.
APA Chen, Jiayu.,Hutchison, Kent E..,Bryan, Angela D..,Filbey, Francesca M..,Calhoun, Vince D..,...&Liu, Jingyu.(2018).Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.FRONTIERS IN PSYCHIATRY,9,12.
MLA Chen, Jiayu,et al."Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention".FRONTIERS IN PSYCHIATRY 9(2018):12.
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