| Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention | |
Chen, Jiayu1; Hutchison, Kent E.1,2; Bryan, Angela D.2; Filbey, Francesca M.3; Calhoun, Vince D.1,4; Claus, Eric D.1; Lin, Dongdong1; Sui, Jing1,5,6 ; Du, Yuhui1,7; Liu, Jingyu1,4
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| 发表期刊 | FRONTIERS IN PSYCHIATRY
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| ISSN | 1664-0640 |
| 2018-11-15 | |
| 卷号 | 9页码:12 |
| 通讯作者 | Chen, Jiayu(jchen@mrn.org) |
| 摘要 | Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various stimuli including exercise. Thus, it is an intriguing question whether exercise can lead to methylation changes that are opposite to those related to drinking. We herein conducted a comparative study to explore this issue. Three cohorts were profiled for DNA methylation (DNAm), including a longitudinal exercise intervention cohort (53 healthy participants profiled at baseline and after a 12-months exercise intervention), a cross-sectional case-control cohort (81 hazardous drinkers and 81 healthy controls matched in age and sex), and a cross-sectional binge drinking cohort (281 drinkers). We identified 906 methylation sites showing significant DNAm differences between drinkers and controls in the case-control cohort, as well as, associations with drinking behavior in the drinking cohort. In parallel, 341 sites were identified for significant DNAm alterations between baseline and follow-up in the exercise cohort. Thirty-two sites overlapped between these two set of findings, of which 15 sites showed opposite directions of DNAm associations between exercise and drinking. Annotated genes of these 15 sites were enriched in signaling pathways related to synaptic plasticity. In addition, the identified methylation sites significantly associated with impaired control over drinking, suggesting relevance to neural function. Collectively, the current findings provide preliminary evidence that exercise has the potential to partially reverse DNAm differences associated with drinking at some CpG sites, motivating rigorously designed longitudinal studies to better characterize epigenetic effects with respect to prevention and intervention of AUD. |
| 关键词 | alcohol exercise methylation impaired control synaptic plasticity |
| DOI | 10.3389/fpsyt.2018.00594 |
| 关键词[WOS] | ACID AMIDE HYDROLASE ; DNA METHYLATION ; RESPONSE-INHIBITION ; ALZHEIMERS-DISEASE ; PHYSICAL-ACTIVITY ; SYNAPTIC FUNCTION ; IMPAIRED CONTROL ; SKELETAL-MUSCLE ; BETA-CATENIN ; DRUG-USE |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Science Foundation EPSCoR grant[1539067] ; National Institutes of Health[R01CA109858] ; National Institutes of Health[R01AA012238] ; National Institutes of Health[1R01EB006841] ; National Institutes of Health[R01EB005846] ; National Institutes of Health[P20GM103472] ; National Institutes of Health[P20GM103472] ; National Institutes of Health[R01EB005846] ; National Institutes of Health[1R01EB006841] ; National Institutes of Health[R01AA012238] ; National Institutes of Health[R01CA109858] ; National Science Foundation EPSCoR grant[1539067] |
| 项目资助者 | National Institutes of Health ; National Science Foundation EPSCoR grant |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | WOS:000450246700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/22621 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Chen, Jiayu |
| 作者单位 | 1.Mind Res Network, Albuquerque, NM USA 2.Univ Colorado Boulder, Dept Psychol & Neurosci, Boulder, CO USA 3.Univ Texas Dallas, Ctr BrainHlth, Sch Behav & Brain Sci, Dallas, TX USA 4.Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA 5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 7.Shanxi Univ, Sch Comp Informat Technol, Taiyuan, Shanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jiayu,Hutchison, Kent E.,Bryan, Angela D.,et al. Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention[J]. FRONTIERS IN PSYCHIATRY,2018,9:12. |
| APA | Chen, Jiayu.,Hutchison, Kent E..,Bryan, Angela D..,Filbey, Francesca M..,Calhoun, Vince D..,...&Liu, Jingyu.(2018).Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.FRONTIERS IN PSYCHIATRY,9,12. |
| MLA | Chen, Jiayu,et al."Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention".FRONTIERS IN PSYCHIATRY 9(2018):12. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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