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Abnormal frontostriatal tracts in young male tobacco smokers
Yuan, Kai1,2,3,4,5; Yu, Dahua4; Zhao, Meng1,3; Li, Min1,3; Wang, Ruonan1,3; Li, Yangding5; Manza, Peter2; Shokri-Kojori, Ehsan2; Wiers, Corinde E.2; Wang, Gene-Jack2; Tian, Jie1,3,6
发表期刊NEUROIMAGE
ISSN1053-8119
2018-12-01
卷号183页码:346-355
通讯作者Yuan, Kai(kyuan@xidian.edu.cn) ; Tian, Jie(tian@ieee.org)
摘要Dysfunctions in frontostriatal circuits have been associated with craving and cognitive control in smokers. However, the relevance of white matter (WM) diffusion properties of the ventral and dorsal frontostriatal tracts for behaviors associated with smoking remains relatively unknown, especially in young adulthood, a critical time period for the development and maintenance of addiction. Here, diffusion tensor imaging (DTI) and probabilistic tractography were used to investigate the WM tracts of the ventral and dorsal frontostriatal circuits in two independent studies (Study1: 36 male smokers (21.3 +/- 1.3 years) vs. 35 male nonsmokers (21.2 +/- 1.3 years); Study2: 29 male smokers (21.4 +/- 1.1 years) vs. 25 male nonsmokers (21.0 +/- 1.4 years)). Subjective craving was measured by the Questionnaire on Smoking Urges (QSU) and cognitive control ability was assessed with the Stroop task. In both studies, smokers committed more response errors than nonsmokers during the incongruent condition of the Stroop task. Relative to controls, smokers showed lower fractional anisotropy (FA) and higher radial diffusivity in left medial orbitofrontal cortex-to-nucleus accumbens fiber tracts (ventral frontostriatal path) and also lower FA in right dorsolateral prefrontal cortex-to-caudate fiber tracts (dorsal frontostriatal path). The FA values of the right dorsal fibers were negatively correlated with incongruent response Stroop errors in smokers, whereas the mean diffusivity values of the left ventral fibers were positively correlated with craving in smokers. Thus, WM diffusion properties of the dorsal and ventral frontostriatal tracts were associated with cognitive control and craving, respectively, in young male tobacco smokers. These data highlight the importance of studying WM in relation to neuropsychological changes underlying smoking.
关键词White matter Smoker Diffusion tensor imaging Craving Cognitive control
DOI10.1016/j.neuroimage.2018.08.046
关键词[WOS]STATE FUNCTIONAL CONNECTIVITY ; WHITE-MATTER INTEGRITY ; COGNITIVE CONTROL ; RESTING-STATE ; RECEPTOR AVAILABILITY ; CIGARETTE SMOKERS ; NUCLEUS-ACCUMBENS ; DOPAMINE RELEASE ; ADDICTION ; BRAIN
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[81871426] ; National Natural Science Foundation of China[81871430] ; National Natural Science Foundation of China[81571751] ; National Natural Science Foundation of China[81571753] ; National Natural Science Foundation of China[61771266] ; National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[81701780] ; Fundamental Research Funds for the Central Universities[JB151204] ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJYT-17-B11] ; Natural Science Foundation of Inner Mongolia[2017MS(LH)0814] ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJZY17262] ; Innovation Fund Project of Inner Mongolia University of Science and Technology[2015QNGG03] ; National Natural Science Foundation of Shaanxi Province[2018JM7075] ; National Institutes of Health, United States[Y1AA3009]
项目资助者National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Natural Science Foundation of Inner Mongolia ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Innovation Fund Project of Inner Mongolia University of Science and Technology ; National Natural Science Foundation of Shaanxi Province ; National Institutes of Health, United States
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000447750200030
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22825
专题中国科学院分子影像重点实验室
通讯作者Yuan, Kai; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.NIAAA, Lab Neuroimaging, Bethesda, MD 20892 USA
3.Engn Res Ctr Mol & Neuroimaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou 014010, Inner Mongolia, Peoples R China
5.Guangxi Normal Univ, Guangxi Key Lab Multisource Informat Min & Secur, Guilin 541004, Guangxi, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Yuan, Kai,Yu, Dahua,Zhao, Meng,et al. Abnormal frontostriatal tracts in young male tobacco smokers[J]. NEUROIMAGE,2018,183:346-355.
APA Yuan, Kai.,Yu, Dahua.,Zhao, Meng.,Li, Min.,Wang, Ruonan.,...&Tian, Jie.(2018).Abnormal frontostriatal tracts in young male tobacco smokers.NEUROIMAGE,183,346-355.
MLA Yuan, Kai,et al."Abnormal frontostriatal tracts in young male tobacco smokers".NEUROIMAGE 183(2018):346-355.
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