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Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle
Du, Yang1,2,3; Fan, Kelong4; Zhang, Hejun5; Li, Li1; Wang, Peixia3,4; He, Jiuyang3,4; Ding, Shigang5; Yan, Xiyun3,4; Tian, Jie1,2,3
发表期刊NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2018-10-01
卷号14期号:7页码:2259-2270
通讯作者Ding, Shigang(dingshigang222@163.com) ; Yan, Xiyun(yanxy@sun5.ibp.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要Optical imaging technologies improve clinical diagnostic accuracy of early gastric cancer (EGC). However, there was a lack of imaging agents exhibiting molecular specificity for EGCs. Here, we employed the dye labeled human heavy-chain ferritin (HFn) as imaging nanoprobe, which recognizes tumor biomarker transferrin receptor 1 (TfR1), to enable specific EGC imaging using confocal laser endomicroscopy (CLE). TfR1 expression was initially examined in vitro in gastric tumor cells and in vivo through whole-body fluorescence and CLE imaging in tumor-bearing mice. Subsequently, dye labeled HFn was topically applied to resected human tissues for EGC detection. CLE analysis of TfR1-targeted fluorescence imaging allowed distinction of neoplastic from non-neoplastic tissues (P < 0.0001), and TfR1 expression level was found to correlate with EGC differentiation degrees (P < 0.0001). Notably, the CLE evaluation correlated well with the immunohistochemical findings (kappa-coefficient: 0.8023). Our HFn-nanoprobe-based CLE increases the accuracy of EGC detection and enables visualization of tumor margins and endoscopic resection. (c) 2018 Elsevier Inc. All rights reserved.
关键词Early gastric cancer Confocal laser endomicroscopy Human H-ferritin Molecular imaging Fluorescently labeled nanoprobe
DOI10.1016/j.nano.2018.07.007
关键词[WOS]IN-VIVO ; CONFOCAL ENDOMICROSCOPY ; PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; RECEPTOR ; NANOCAGES ; TUMORS
收录类别SCI
语种英语
资助项目Ministry of Science and Technology of China[2016YFA0201404] ; Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81201186] ; National Natural Science Foundation of China[31530026] ; National Natural Science Foundation of China[81671810] ; Research and Development Program of China (973)[2015CB755500] ; Young Elite Scientist Sponsorship Program by CAST[2015QNRC001] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDB02060010] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDA09030306] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SMC013]
项目资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Research and Development Program of China (973) ; Young Elite Scientist Sponsorship Program by CAST ; Strategic Priority Research Program from Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号WOS:000446496900026
出版者ELSEVIER SCIENCE BV
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23047
专题中国科学院分子影像重点实验室
通讯作者Ding, Shigang; Yan, Xiyun; Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Beijing Key Lab Helicobacter Pylori Infect & Uppe, Dept Gastroenterol, Beijing, Peoples R China
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Du, Yang,Fan, Kelong,Zhang, Hejun,et al. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2018,14(7):2259-2270.
APA Du, Yang.,Fan, Kelong.,Zhang, Hejun.,Li, Li.,Wang, Peixia.,...&Tian, Jie.(2018).Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,14(7),2259-2270.
MLA Du, Yang,et al."Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.7(2018):2259-2270.
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