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Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments
Du Yang; Xiaolong Liang; Yuan Li; Ting Sun; Huadan Xue; Zhengyu Jin; Jie Tian
发表期刊Cancer Letters
2018-02-01
期号414页码:230-238
摘要

Programmed death ligand-1 (PD-L1) is a central element in cancer therapies targeting immune check­points, and its expression is an important predictor of the therapeutic response. With recent approvals of therapeutic antibodies against PD-L1 and PD-1, noninvasive detection methods are now urgently needed to quantify PD-L1 expression in tumors and to evaluate the response to immune therapies. However, only few such methods are available. Thus, we fabricated nanohybrid liposomal cerasome nanoparticles loaded with the chemotherapeutic drug paclitaxel, and evaluated their value as a theranostic agent. The particles are also decorated with PD-L1 antibody to enable specic targeting, and are dual-labeled to enable near-infrared uorescence (NIRF) and magnetic resonance imaging (MRI) in vivo. Results showed that in vivo NIRF and MRI imaging following intravenous injection of cerasomes revealed a strong pos­itive contrast for tumors, indicating long-lived enhancement of relevant signals. Moreover, the cerasomes were more effective against tumors and metastasis in comparison to simultaneous but nontargeted delivery of PD-L1 antibody and paclitaxel. Taken together, the data indicate that targeted, dual-labeled cerasomes are good theranostic agents for MRI/NIRF dual-mode detection and treatment of solid tu­mors in situ.

关键词Programmed Cell Death Ligand-1, Near Infrared FLuorescence, Magnetic Resonance Imaging, Paclitaxel, Chemotherapy, Immunotherapy
语种英语
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23177
专题中国科学院分子影像重点实验室
通讯作者Zhengyu Jin; Jie Tian
推荐引用方式
GB/T 7714
Du Yang,Xiaolong Liang,Yuan Li,et al. Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments[J]. Cancer Letters,2018(414):230-238.
APA Du Yang.,Xiaolong Liang.,Yuan Li.,Ting Sun.,Huadan Xue.,...&Jie Tian.(2018).Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments.Cancer Letters(414),230-238.
MLA Du Yang,et al."Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments".Cancer Letters .414(2018):230-238.
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