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Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin
Du Yang; Fan Kelong; Zhang Hejun; Li Li; Wang Peixia; He Jiuyang; Ding Shigang; Yang Xiyun; Tian Jie
发表期刊Nanomedicine-Nanotechnology Biology and Medicine
2018-10
卷号14期号:7页码:2259-2270
摘要

Optical imaging technologies improve clinical diagnostic accuracy of early gastric cancer (EGC). However, there was a lack of imaging agents exhibiting molecular specificity for EGCs. Here, we employed the dye labeled human heavy-chain ferritin (HFn) as imaging nanoprobe, which recognizes tumor biomarker transferrin receptor 1 (TfR1), to enable specific EGC imaging using confocal laser endomicroscopy (CLE). TfR1 expression was initially examined in vitro in gastric tumor cells and in vivo through whole-body fluorescence and CLE imaging in tumor-bearing mice. Subsequently, dye labeled HFn was topically applied to resected human tissues for EGC detection. CLE analysis of TfR1-targeted fluorescence imaging allowed distinction of neoplastic from non-neoplastic tissues (P b 0.0001), and TfR1 expression level was found to correlate with EGC differentiation degrees (P b 0.0001). Notably, the CLE evaluation correlated well with the immunohistochemical findings (κ-coefficient: 0.8023). Our HFn-nanoprobe-based CLE increases the accuracy of EGC detection and enables visualization of tumor margins and endoscopic resection.

关键词Early Gastric Cancer Confocal Laser Endomicroscopy Human H-ferritin Molecular Imaging Fluorescently Labeled Nanoprobe
DOI10.1016/j.nano.2018.07.007.
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23178
专题中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Du Yang,Fan Kelong,Zhang Hejun,et al. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin[J]. Nanomedicine-Nanotechnology Biology and Medicine,2018,14(7):2259-2270.
APA Du Yang.,Fan Kelong.,Zhang Hejun.,Li Li.,Wang Peixia.,...&Tian Jie.(2018).Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin.Nanomedicine-Nanotechnology Biology and Medicine,14(7),2259-2270.
MLA Du Yang,et al."Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin".Nanomedicine-Nanotechnology Biology and Medicine 14.7(2018):2259-2270.
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