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Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression
Li Li; Du Yang; Xiang Dehui; Chen Liang; Shi Zhifeng; Tian Jie; Chen Xinjian
发表期刊Biomedical Optics Express
2018-06-20
卷号9期号:7页码:3193-3207
摘要

Currently, there is no effective way to assess the therapeutic response of temozolomide (TMZ) for the glioma. In this study, the human U87MG-fLuc glioma animal models were set up and the antitumor efficacy of TMZ was evaluated using bioluminescence imaging (BLI) and MRI. Then, bioluminescence tomography (BLT) was reconstructed using an adaptive sparsity matching pursuit (ASMP) algorithm. Second, the expression level of the MMP-750 probe was examined with or without TMZ treatment using FMI. Third, the expression of MMP2 and MMP3 was specifically examined after treatment. The results showed that TMZ effectively inhibited glioma growth. The targeted imaging of MMP-750 was decreased during the treatment of glioma with TMZ. Moreover, the MMP2 and MMP3 expression was found to correlate with the inhibition effect of TMZ. Our study indicated that the therapeutic effects of TMZ can be effectively evaluated at an early stage using molecular imaging, and MMP targeting the fluorescence probe could be utilized for the prediction and assessment of the therapeutic effects of TMZ.

关键词Mdical And Biological Imaging, Tomographic Imaging, Spectroscopy, Fluorescence And Luminescence, Optical Diagnosis For Medicine
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23181
专题中国科学院分子影像重点实验室
通讯作者Du Yang; Tian Jie; Chen Xinjian
推荐引用方式
GB/T 7714
Li Li,Du Yang,Xiang Dehui,et al. Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression[J]. Biomedical Optics Express,2018,9(7):3193-3207.
APA Li Li.,Du Yang.,Xiang Dehui.,Chen Liang.,Shi Zhifeng.,...&Chen Xinjian.(2018).Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression.Biomedical Optics Express,9(7),3193-3207.
MLA Li Li,et al."Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression".Biomedical Optics Express 9.7(2018):3193-3207.
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