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Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier
Li Juan; Du Yang; Jiang zhengqi; Tian Yuchen; Qiu Nianxiang; Wang yinjie; Muhammad Zubair lqbal; Hu Menying; Zou Ruifen; Luo Lijia; Du Shiyu; Tian Jie; Wu aiguo
发表期刊Nanoscale
2018-03-29
卷号10期号:13页码:5845-5851
摘要

Due to the molecular and cellular heterogeneity of glioma, discov­ery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo uorescent imaging that a highly selective Y1R ligand, [Asn6,Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nano­micelles specically targeting glioma. Modication with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physio­logical state and promoted drug release in the acidic tumor micro-environment. Furthermore, targeted delivery of AP-NPY nano­micelles improved the therapeutic ecacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.

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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23183
专题中国科学院分子影像重点实验室
通讯作者Tian Jie; Wu aiguo
推荐引用方式
GB/T 7714
Li Juan,Du Yang,Jiang zhengqi,et al. Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier[J]. Nanoscale,2018,10(13):5845-5851.
APA Li Juan.,Du Yang.,Jiang zhengqi.,Tian Yuchen.,Qiu Nianxiang.,...&Wu aiguo.(2018).Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier.Nanoscale,10(13),5845-5851.
MLA Li Juan,et al."Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier".Nanoscale 10.13(2018):5845-5851.
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