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Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease
Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X
发表期刊Aging Clin Exp Res
2016
卷号28期号:5页码:951-7
摘要BACKGROUND AND AIMS: Rapid eye movement (REM) sleep behavior disorder (RBD) is commonly associated with neurodegenerative disorders characterized by alpha-synuclein deposition, including Parkinson's disease, multiple system atrophy, and Lewy body dementia. However, this tendency in tauopathy-mediated diseases is rare and only sporadically reported. We systematically illustrate the occurrence of RBD and sleep features among a cohort of patients with Alzheimer's disease (AD), a non-synucleinopathy. METHODS: We recruited 105 clinically probable AD patients. Fifteen clinically probable AD patients with suspected RBD underwent a video-polysomnography (vPSG) examination. RESULTS: Five patients with probable AD exhibited RBD. One of the patients performed repeated touching of the head and the face with his hands and flailed his arms. Three patients exhibited hand twisting, exploring, prominent limb kicking, and jerking. The fifth patient exhibited all of the characteristics of RBD (he recalled a dream about fighting animals), and his wife was awakened by his screaming. Of these five patients, one patient took the acetylcholinesterase inhibitor drug donepezil. The patients with AD + RBD demonstrated increases in both tonic and phasic electromyography activity during REM sleep, but sleep architecture did not differ between the AD + RBD and AD-alone groups. CONCLUSION: RBD can occur in patients with AD. The occurrence of RBD does not change the sleep architecture of AD patients.
关键词Aged,Aged, 80 and over,Alzheimer Disease/*complications,Animals,Cholinesterase Inhibitors/therapeutic use,Electromyography,Female,Humans,Male,Middle Aged,Polysomnography,Probability,REM Sleep BehaviorDisorder/*epidemiology,Sleep/physiology,Sleep, REM/*physiology,Alzheimer's disease,REM sleep behavior disorder,REM sleep without atonia,Video-polysomnography
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23225
专题脑网络组研究中心
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GB/T 7714
Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X. Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease[J]. Aging Clin Exp Res,2016,28(5):951-7.
APA Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X.(2016).Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease.Aging Clin Exp Res,28(5),951-7.
MLA Wang, P, Wing, Y. K, Xing, J, Liu, Y, Zhou, B, Zhang, Z, Yao, H, Guo, Y, Shang, Y, Zhang, X."Rapid eye movement sleep behavior disorder in patients with probable Alzheimer's disease".Aging Clin Exp Res 28.5(2016):951-7.
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