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Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex
Guyue Hu; Xuhui Huang; Tianzi Jiang; Shan Yu
Source PublicationFrontiers in physiology
2019
Volume10Issue:113Pages:3389
SubtypeArticle
Abstract

The prefrontal cortex (PFC), which plays key roles inmany higher cognitive processes, is a hierarchical system consisting of multi-scale organizations. Optimizing the working state at each scale is essential for PFC’s information processing. Typical optimal working states at different scales have been separately reported, including the dopamine-mediated inverted-U profile of the working memory (WM) at the system level, critical dynamics at the network level, and detailed balance of excitatory and inhibitory currents (E/I balance) at the cellular level. However, it remains unclear whether these states are scale-specific expressions of the same optimal state and, if so, what is the underlying mechanism for its regulation traversing across scales. Here, by studying a neural network model, we show that the optimal performance of WM co-occurs with the critical dynamics at the network level and the E/I balance at the level of individual neurons, suggesting the existence of a unified, multi-scale optimal state for the PFC. Importantly, such a state could be modulated by dopamine at the synaptic level through a series of U or inverted-U profiles. These results suggest that seemingly different optimal states for specific scales are multi-scale expressions of one condition regulated by dopamine. Our work suggests a cross-scale perspective to understand the PFC function and its modulation.

KeywordOptimal States E/i Balance Dopamine The Pfc Working Memory Criticality
Indexed BySCI
Language英语
WOS IDWOS:000459873900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23232
Collection脑网络组研究中心
Corresponding AuthorShan Yu
Recommended Citation
GB/T 7714
Guyue Hu,Xuhui Huang,Tianzi Jiang,et al. Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex[J]. Frontiers in physiology,2019,10(113):3389.
APA Guyue Hu,Xuhui Huang,Tianzi Jiang,&Shan Yu.(2019).Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex.Frontiers in physiology,10(113),3389.
MLA Guyue Hu,et al."Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex".Frontiers in physiology 10.113(2019):3389.
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