Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex | |
Guyue Hu1,2,5; Xuhui Huang1,2,3,4; Tianzi Jiang1,2,4,5; Shan Yu1,2,4,5 | |
发表期刊 | Frontiers in physiology |
2019 | |
卷号 | 10期号:113页码:3389 |
文章类型 | Article |
摘要 | The prefrontal cortex (PFC), which plays key roles inmany higher cognitive processes, is a hierarchical system consisting of multi-scale organizations. Optimizing the working state at each scale is essential for PFC’s information processing. Typical optimal working states at different scales have been separately reported, including the dopamine-mediated inverted-U profile of the working memory (WM) at the system level, critical dynamics at the network level, and detailed balance of excitatory and inhibitory currents (E/I balance) at the cellular level. However, it remains unclear whether these states are scale-specific expressions of the same optimal state and, if so, what is the underlying mechanism for its regulation traversing across scales. Here, by studying a neural network model, we show that the optimal performance of WM co-occurs with the critical dynamics at the network level and the E/I balance at the level of individual neurons, suggesting the existence of a unified, multi-scale optimal state for the PFC. Importantly, such a state could be modulated by dopamine at the synaptic level through a series of U or inverted-U profiles. These results suggest that seemingly different optimal states for specific scales are multi-scale expressions of one condition regulated by dopamine. Our work suggests a cross-scale perspective to understand the PFC function and its modulation. |
关键词 | Optimal States E/I Balance Dopamine The PFC Working Memory Criticality |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000459873900001 |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/23232 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Shan Yu |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Tech, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China |
第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
通讯作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Guyue Hu,Xuhui Huang,Tianzi Jiang,et al. Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex[J]. Frontiers in physiology,2019,10(113):3389. |
APA | Guyue Hu,Xuhui Huang,Tianzi Jiang,&Shan Yu.(2019).Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex.Frontiers in physiology,10(113),3389. |
MLA | Guyue Hu,et al."Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex".Frontiers in physiology 10.113(2019):3389. |
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