CASIA OpenIR  > 中国科学院分子影像重点实验室
Bioluminescence Tomography Based on Bilateral Weight Laplace method for In vivo Morphological Imaging of Glioma
Gao, Yuan1,2; Wang, Kun1,2; Meng, Hui1,2; An, Yu1,2; Jiang, Shixin4; Tian, Jie1,3
Conference Name2019 Society of Photo-Optical Instrumentation Engineers (SPIE), BiOS
Conference Date2019.02.01
Conference PlaceSan Francisco, USA

The development of Bioluminescence Tomography (BLT) has allowed the quantitative three dimension (3D) whole body imaging and non-invasive study of biological behavior of cancer. However, the ill-posed problem of BLT reconstruction limits the quality of reconstruction result. In this work, we proposed a Bilateral Weight Laplace (BWL) method that utilizes a non-local Laplace regularization to improve the imaging quality of bioluminescence tomography reconstruction. The non-local Laplace regularization was constructed by spatial weight and range weight to penalize the neighborhood-variance of reconstructed source density in both spatial and range domain. To evaluate the performance of BWL method, both dual-source BLT reconstruction experiment in simulation data and in vivo BLT reconstruction in orthotopic glioma mouse model were designed. Furthermore, fast iterative shrinkage/threshold (FIST) method and Laplace method were utilized to compare with BWL. Both dual-source experiment and in vivo experiment demonstrate that the construction results of BWL method provide more accurate tumor position (BCE = 0.37mm in dual-source experiment) and better tumor morphological information

Indexed ByEI
Sub direction classification医学影像处理与分析
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Document Type会议论文
Corresponding AuthorTian, Jie
Affiliation1.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, 100190, China
2.The University of Chinese Academy of Sciences, Beijing, 100049, China
3.Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, 100191, China
4.Beijing Jiaotong University, Beijing, 100044, China
Recommended Citation
GB/T 7714
Gao, Yuan,Wang, Kun,Meng, Hui,et al. Bioluminescence Tomography Based on Bilateral Weight Laplace method for In vivo Morphological Imaging of Glioma[C],2019.
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