CASIA OpenIR  > 脑网络组研究中心
Genetic influences on cortical myelination in the human brain
Liu, Shu1,2,3; Li, Ang1,2,3; Zhu, Meifang1,2,3; Li, Jin1,2; Liu, Bing1,2,3,4
Source PublicationGENES BRAIN AND BEHAVIOR
ISSN1601-1848
2019-04-01
Volume18Issue:4Pages:7
Corresponding AuthorLi, Jin(jli@nlpr.ia.ac.cn) ; Liu, Bing(bliu@nlpr.ia.ac.cn)
AbstractCortical myelination, which is essential for interneuronal communication and neurodevelopment, has been reported to be under genetic control. However, the degree to which genes contribute to the variability of myelination, the pattern of genetic control, and how genes influence the organization of myelination are largely unknown. To answer these questions, the present study calculated heritability estimates for myelination of the cortical regions using the high quality structural magnetic resonance imaging (MRI) scans from the Human Connectome Project pedigree cohort (n = 873, 383/490 M/F, 22-36 years of age). Then, we used transcriptional profiles to evaluate the contribution of myelination-related genes (data from the Allen Human Brain Atlas) to explain interregional variations in cortical myelination. Our results showed that all the cortical areas were modestly to moderately influenced by genetic factors (h(2) = 29%-66%, all Ps < 0.05 after Bonferroni correction). The genetic control of cortical myelination showed bilateral symmetry and an anterior-to-posterior gradation. A bivariate model indicated that the regions are strongly genetically correlated with their homologs in the opposite cerebral hemisphere. A cross-modal analysis did not find a correlation between cortical myelination and the expression levels of myelination-related genes. This could have been due to the small number of samples with expression data in each cortical region. Overall, our findings suggest that cortical myelination is shaped by genetic factors and may be useful to bridge the underlying genetic variants and the cognitive functioning and related neuropsychiatric disorders.
KeywordAllen Brain Institute cerebral cortex gene expression genetics heritability Human Connectome Project imaging myelin map myelination structural MRI
DOI10.1111/gbb.12537
WOS KeywordHUMAN CONNECTOME PROJECT ; TRAIT LINKAGE ANALYSIS ; WHITE-MATTER ; CORTEX ; HERITABILITY ; DISRUPTION ; EXPRESSION ; CONDUCTION ; ATLAS ; SIZE
Indexed BySCI
Language英语
Funding ProjectOpen Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB1509] ; Natural Science Foundation of China[31571150] ; Natural Science Foundation of China[81771393] ; Natural Science Foundation of China[91432304] ; Natural Science Foundation of China[81771451] ; National Key Research and Development Plan[2016YFC0904300]
Funding OrganizationOpen Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Natural Science Foundation of China ; National Key Research and Development Plan
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000467974400008
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23608
Collection脑网络组研究中心
Corresponding AuthorLi, Jin; Liu, Bing
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shu,Li, Ang,Zhu, Meifang,et al. Genetic influences on cortical myelination in the human brain[J]. GENES BRAIN AND BEHAVIOR,2019,18(4):7.
APA Liu, Shu,Li, Ang,Zhu, Meifang,Li, Jin,&Liu, Bing.(2019).Genetic influences on cortical myelination in the human brain.GENES BRAIN AND BEHAVIOR,18(4),7.
MLA Liu, Shu,et al."Genetic influences on cortical myelination in the human brain".GENES BRAIN AND BEHAVIOR 18.4(2019):7.
Files in This Item: Download All
File Name/Size DocType Version Access License
gbb.12537.pdf(625KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Zhu, Meifang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Zhu, Meifang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Zhu, Meifang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: gbb.12537.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.