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Genetic influences on cortical myelination in the human brain | |
Liu, Shu1,2,3![]() ![]() ![]() ![]() ![]() | |
发表期刊 | GENES BRAIN AND BEHAVIOR
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ISSN | 1601-1848 |
2019-04-01 | |
卷号 | 18期号:4页码:7 |
通讯作者 | Li, Jin(jli@nlpr.ia.ac.cn) ; Liu, Bing(bliu@nlpr.ia.ac.cn) |
摘要 | Cortical myelination, which is essential for interneuronal communication and neurodevelopment, has been reported to be under genetic control. However, the degree to which genes contribute to the variability of myelination, the pattern of genetic control, and how genes influence the organization of myelination are largely unknown. To answer these questions, the present study calculated heritability estimates for myelination of the cortical regions using the high quality structural magnetic resonance imaging (MRI) scans from the Human Connectome Project pedigree cohort (n = 873, 383/490 M/F, 22-36 years of age). Then, we used transcriptional profiles to evaluate the contribution of myelination-related genes (data from the Allen Human Brain Atlas) to explain interregional variations in cortical myelination. Our results showed that all the cortical areas were modestly to moderately influenced by genetic factors (h(2) = 29%-66%, all Ps < 0.05 after Bonferroni correction). The genetic control of cortical myelination showed bilateral symmetry and an anterior-to-posterior gradation. A bivariate model indicated that the regions are strongly genetically correlated with their homologs in the opposite cerebral hemisphere. A cross-modal analysis did not find a correlation between cortical myelination and the expression levels of myelination-related genes. This could have been due to the small number of samples with expression data in each cortical region. Overall, our findings suggest that cortical myelination is shaped by genetic factors and may be useful to bridge the underlying genetic variants and the cognitive functioning and related neuropsychiatric disorders. |
关键词 | Allen Brain Institute cerebral cortex gene expression genetics heritability Human Connectome Project imaging myelin map myelination structural MRI |
DOI | 10.1111/gbb.12537 |
关键词[WOS] | HUMAN CONNECTOME PROJECT ; TRAIT LINKAGE ANALYSIS ; WHITE-MATTER ; CORTEX ; HERITABILITY ; DISRUPTION ; EXPRESSION ; CONDUCTION ; ATLAS ; SIZE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key Research and Development Plan[2016YFC0904300] ; Natural Science Foundation of China[81771451] ; Natural Science Foundation of China[91432304] ; Natural Science Foundation of China[81771393] ; Natural Science Foundation of China[31571150] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB1509] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB1509] ; Natural Science Foundation of China[31571150] ; Natural Science Foundation of China[81771393] ; Natural Science Foundation of China[91432304] ; Natural Science Foundation of China[81771451] ; National Key Research and Development Plan[2016YFC0904300] |
项目资助者 | Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Natural Science Foundation of China ; National Key Research and Development Plan |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000467974400008 |
出版者 | WILEY |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/23608 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Li, Jin; Liu, Bing |
作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Zhongguancun East Rd 95, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing, Peoples R China |
第一作者单位 | 模式识别国家重点实验室 |
通讯作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Shu,Li, Ang,Zhu, Meifang,et al. Genetic influences on cortical myelination in the human brain[J]. GENES BRAIN AND BEHAVIOR,2019,18(4):7. |
APA | Liu, Shu,Li, Ang,Zhu, Meifang,Li, Jin,&Liu, Bing.(2019).Genetic influences on cortical myelination in the human brain.GENES BRAIN AND BEHAVIOR,18(4),7. |
MLA | Liu, Shu,et al."Genetic influences on cortical myelination in the human brain".GENES BRAIN AND BEHAVIOR 18.4(2019):7. |
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