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Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer
Jin YS(靳玉慎)1,2; Li YY(李妍妍)3; Yang X(杨鑫)1,2; Tian J(田捷)1,2,4,5
Source PublicationActa Biomaterialia
2019
Issue97Pages:223-234
SubtypeSCI
Abstract

Neuroblastoma accounts for 8–10% of malignancies in infants and children. It is urgent to develop an appropriate theranostic agent for effective diagnosis and therapy of neuroblastoma. Herein, we constructed RVG peptide and IRDye800-conjugated bovine serum albumin-coated triangular gadolinium oxide nanoplates (RVG&IRDye800-Gd2O3 TNs) as a targeting MRI agent for the diagnosis of neuroblastoma preoperation and a fluorescence imaging agent for the guidance of the precise excision of the neuroblastoma in surgery. RVG&IRDye800-Gd2O3 TNs have uniform edge length. The RVG&IRDye800-Gd2O3 TNs show remarkably enhanced affinity to both mouse- and human-derived neuroblastoma cells compared with IRDye800-Gd2O3 TNs (3.07-fold and 3.02-fold, respectively). Because of the increased accumulation in tumor cells, RVG&IRDye800-Gd2O3 TNs exhibit signals threefold to fivefold higher than the surrounding normal tissues, which is propitious to the diagnosis of neuroblastoma preoperation and provides real-time visual guidance of the precise excision of the neuroblastoma. Most importantly, with the guidance of the fluorescence imaging agent, the survival rate increased from 0% to 80% 42 days after surgery compared with that in conventional surgery. These findings indicated that the RVG peptide combined with IRDye800-Gd2O3 TNs has the potential to improve the diagnosis and treatment of patients with neuroblastoma

KeywordTriangular Gadolinium Oxide Nanoplates Fluorescence Imaging Mri Imaging Imaging-guided Excision
MOST Discipline Catalogue工学
DOI10.1016/j.actbio.2019.01.042
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23664
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian J(田捷)
Affiliation1.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
2.Beijing Key Laboratory Molecular Imaging, Beijing 100190, China
3.Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China
4.The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
5.University of Chinese Academy of Sciences, Beijing 100080, China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jin YS,Li YY,Yang X,et al. Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer[J]. Acta Biomaterialia,2019(97):223-234.
APA Jin YS,Li YY,Yang X,&Tian J.(2019).Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer.Acta Biomaterialia(97),223-234.
MLA Jin YS,et al."Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer".Acta Biomaterialia .97(2019):223-234.
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