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MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex
Liu Shu; Li Ang; Liu Yong; Li Jin; Wang Meng; Sun Yuqing; Qin Wen; Yu Chunshui; Jiang Tianzi; Liu Bing
Source PublicationPsychological Medicine
2019
IssuePages:
Abstract

Background. Genome-wide association studies (GWAS) have consistently revealed that a variant of microRNA 137 (MIR137) shows a quite significant association with schizophrenia. Identifying the network of genes regulated by MIR137 could provide insights into the biological processes underlying schizophrenia. In addition, DLPFC functional connectivity, a robust correlate of MIR137, may provide plausible endophenotypes. However, the regulatory role of the MIR137 gene network in the disrupted functional connectivity remains unclear. Here, we tested the effects of the MIR137 regulated genes on the risk for schizophrenia and DLPFC functional connectivity.
Methods. To evaluate the additive effects of the MIR137 regulated genes (N = 1274), we calculated a MIR137 polygenic risk score (PRS) for schizophrenia and tested its association with the risk for schizophrenia in the genomic data of a Han Chinese population that included schizophrenia patients (N = 589) and normal controls (N = 575). We then investigated the association between MIR137 PRS and DLPFC functional connectivity in two independent young healthy cohorts (N = 356 and N = 314).
Results. We found that the MIR137 PRS successfully captured the differences in genetic structure between the patients and controls, but the single gene MIR137 did not. We then consistently found that a higher MIR137 PRS was correlated with lower functional connectivities between the DLPFC and both the superior parietal cortex and the inferior temporal cortex in two independent cohorts.
Conclusion. The findings suggested that these two functional connectivities of the DLPFC could be important endophenotypes linking the MIR137-regulated genetic structure to schizophrenia.

KeywordDorsolateral Prefrontal Cortex Functional Connectivity Microrna-137 Polygenic Risk Score Schizophrenia
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23895
Collection脑网络组研究中心
Corresponding AuthorLiu Bing
Affiliation1.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
3.CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences
4.Department of Radiology, Tianjin Medical University General Hospital
5.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China
6.Queensland Brain Intute, University of Queensland
Recommended Citation
GB/T 7714
Liu Shu,Li Ang,Liu Yong,et al. MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex[J]. Psychological Medicine,2019(无):无.
APA Liu Shu.,Li Ang.,Liu Yong.,Li Jin.,Wang Meng.,...&Liu Bing.(2019).MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.Psychological Medicine(无),无.
MLA Liu Shu,et al."MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex".Psychological Medicine .无(2019):无.
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