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Schizophrenia-related abnormalities in the triple network: A meta-analysis of working memory studies | |
Wu DY(吴东亚) | |
发表期刊 | Brain Imaging and Behavior |
ISSN | 1931-7557 |
2019 | |
卷号 | 14期号:暂无页码:暂无 |
通讯作者 | Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) |
文章类型 | Original research |
摘要 | Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the default mode network have also been reported in schizophrenia but have received less attention. Our goal was to discover whether deactivation abnormalities can also be consistently found in schizophrenia during working memory tasks and, further, to consider both activation and deactivation abnormalities. Fifty-two English language peer-reviewed studies were included in this meta-analysis. Compared with normal controls, the schizophrenia patients showed activation dysfunction of the bilateral dorsolateral prefrontal cortex and posterior parietal cortex as well as the anterior insula, anterior cingulate cortex, and supplementary motor area, which are core nodes of the central executive and salience network. In addition to dysfunction of the activation networks, the patients showed deactivation abnormalities in the ventral medial prefrontal cortex and posterior cingulate cortex, which are core nodes of the default mode network. These results suggest that both activation and deactivation abnormalities exist in schizophrenia patients and that these abnormalities should both be considered when investigating the pathophysiological mechanism of schizophrenia. |
关键词 | Schizophrenia, Meta-analysis, Neuroimaging, Working Memory |
DOI | 10.1007/s11682-019-00071-1 |
关键词[WOS] | DORSOLATERAL PREFRONTAL CORTEX ; SCALE BRAIN NETWORKS ; DISTRIBUTED NEURAL CIRCUITRY ; LONG-TERM-MEMORY ; FUNCTIONAL CONNECTIVITY ; PHYSIOLOGICAL DYSFUNCTION ; ACTIVATION ; FMRI ; PERFORMANCE ; SALIENCE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Natural Science Foundation of China[81501179] |
项目资助者 | Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neuroimaging |
WOS记录号 | WOS:000552051500003 |
出版者 | SPRINGER |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/23910 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 80146-中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Wu DY. Schizophrenia-related abnormalities in the triple network: A meta-analysis of working memory studies[J]. Brain Imaging and Behavior,2019,14(暂无):暂无. |
APA | Wu DY.(2019).Schizophrenia-related abnormalities in the triple network: A meta-analysis of working memory studies.Brain Imaging and Behavior,14(暂无),暂无. |
MLA | Wu DY."Schizophrenia-related abnormalities in the triple network: A meta-analysis of working memory studies".Brain Imaging and Behavior 14.暂无(2019):暂无. |
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manuscript_final.pdf(538KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 |
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