Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis

doi:10.1021/acsami.8b20600

	Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis
	Deng, Han 1,2,4; Shang, Wenting2 ; Lu, Guanhua 1,2; Guo, Pengyu 2; Ai, Ting 1,2,4; Fang, Chihua 1,4; Tian, Jie 2,3
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
	2019-04-24
卷号	11 期号:16 页码:14526-14537
通讯作者	Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Continuously updated diagnostic methods and advanced imaging methods have led to an increase in the early detection rate of small liver cancer; however, even with current diagnosis methods, it is still challenging to accurately judge a nodule with a diameter less than 2 cm whether it is hepatocellular carcinoma or liver cirrhosis. To solve this issue, a new technology is needed to distinguish above two kinds of liver nodules. There is an emerging imaging method that improves tissue resolution and sensitivity to detect micronodules with diameters less than 2 cm. To detect micronodules, photoacoustic imaging was used to provide noninvasive images at depths of several centimeters with a resolution of approximately 100 mu m. To improve specificity, we developed a probe that specifically targets hepatocellular carcinoma by recognizing the biomarker GPC3 on the hepatocellular carcinoma cell membrane. The probe not only has a strong photoacoustic signal but also has a magnetic resonance signal. Furthermore, the material owns photothermal effect that absorbs longer wavelength light and releases heat that effectively and accurately kills tumor cells, thus improving patient's survival and postoperative quality of life. Herein, we present a new technology that uses photoacoustic imaging to image and target microhepatocellular carcinoma biological processes derived from liver cirrhosis with high spatial resolution.
关键词	small hepatocellular carcinoma liver cirrhosis differential diagnosis photoacoustic imaging GPC3 photothermal therapy
DOI	10.1021/acsami.8b20600
关键词[WOS]	PHOTOACOUSTIC TOMOGRAPHY ; GLYPICAN-3 ; RECURRENCE ; STRATEGY ; CT ; EXPRESSION ; MANAGEMENT ; RESECTION ; THERAPY ; MARKER
收录类别	SCI
语种	英语
资助项目	Government of Guangdong Province[U1401254] ; Digital Theranostic Equipment Research Special Program of The 13th five-year National Key Research Plan[2016YFC0106500] ; Science and Technology Plan Project of Guangzhou[201604020144] ; NSFC-GD Union Foundation[U1401254] ; National Natural Science Foundation of China[U1401254] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81401471] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81601576] ; National Key R&D Program of China[2017YFA0205200] ; Major Instrument Project of the National Natural Science Fund[81627805] ; Major Instrument Project of the National Natural Science Fund[81627805] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81601576] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81401471] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[U1401254] ; NSFC-GD Union Foundation[U1401254] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan[2016YFC0106500] ; Government of Guangdong Province[U1401254]
项目资助者	Major Instrument Project of the National Natural Science Fund ; National Key R&D Program of China ; National Natural Science Foundation of China ; NSFC-GD Union Foundation ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan ; Government of Guangdong Province
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000466052800004
出版者	AMER CHEMICAL SOC
七大方向——子方向分类	其他
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24186
专题	中国科学院分子影像重点实验室
通讯作者	Fang, Chihua; Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beihang Univ, Beijing 100080, Peoples R China 4.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Guangdong, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Deng, Han,Shang, Wenting,Lu, Guanhua,et al. Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(16):14526-14537.
APA	Deng, Han.,Shang, Wenting.,Lu, Guanhua.,Guo, Pengyu.,Ai, Ting.,...&Tian, Jie.(2019).Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis.ACS APPLIED MATERIALS & INTERFACES,11(16),14526-14537.
MLA	Deng, Han,et al."Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis".ACS APPLIED MATERIALS & INTERFACES 11.16(2019):14526-14537.