CASIA OpenIR
Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis
Deng, Han1,2,4; Shang, Wenting2; Lu, Guanhua1,2; Guo, Pengyu2; Ai, Ting1,2,4; Fang, Chihua1,4; Tian, Jie2,3
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
2019-04-24
Volume11Issue:16Pages:14526-14537
Corresponding AuthorFang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractContinuously updated diagnostic methods and advanced imaging methods have led to an increase in the early detection rate of small liver cancer; however, even with current diagnosis methods, it is still challenging to accurately judge a nodule with a diameter less than 2 cm whether it is hepatocellular carcinoma or liver cirrhosis. To solve this issue, a new technology is needed to distinguish above two kinds of liver nodules. There is an emerging imaging method that improves tissue resolution and sensitivity to detect micronodules with diameters less than 2 cm. To detect micronodules, photoacoustic imaging was used to provide noninvasive images at depths of several centimeters with a resolution of approximately 100 mu m. To improve specificity, we developed a probe that specifically targets hepatocellular carcinoma by recognizing the biomarker GPC3 on the hepatocellular carcinoma cell membrane. The probe not only has a strong photoacoustic signal but also has a magnetic resonance signal. Furthermore, the material owns photothermal effect that absorbs longer wavelength light and releases heat that effectively and accurately kills tumor cells, thus improving patient's survival and postoperative quality of life. Herein, we present a new technology that uses photoacoustic imaging to image and target microhepatocellular carcinoma biological processes derived from liver cirrhosis with high spatial resolution.
Keywordsmall hepatocellular carcinoma liver cirrhosis differential diagnosis photoacoustic imaging GPC3 photothermal therapy
DOI10.1021/acsami.8b20600
WOS KeywordPHOTOACOUSTIC TOMOGRAPHY ; GLYPICAN-3 ; RECURRENCE ; STRATEGY ; CT ; EXPRESSION ; MANAGEMENT ; RESECTION ; THERAPY ; MARKER
Indexed BySCI
Language英语
Funding ProjectMajor Instrument Project of the National Natural Science Fund[81627805] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81601576] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81401471] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[U1401254] ; NSFC-GD Union Foundation[U1401254] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan[2016YFC0106500] ; Government of Guangdong Province[U1401254]
Funding OrganizationMajor Instrument Project of the National Natural Science Fund ; National Key R&D Program of China ; National Natural Science Foundation of China ; NSFC-GD Union Foundation ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of the 13th five-year National Key Research Plan ; Government of Guangdong Province
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000466052800004
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24186
Collection中国科学院自动化研究所
Corresponding AuthorFang, Chihua; Tian, Jie
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beihang Univ, Beijing 100080, Peoples R China
4.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Guangdong, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Deng, Han,Shang, Wenting,Lu, Guanhua,et al. Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(16):14526-14537.
APA Deng, Han.,Shang, Wenting.,Lu, Guanhua.,Guo, Pengyu.,Ai, Ting.,...&Tian, Jie.(2019).Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis.ACS APPLIED MATERIALS & INTERFACES,11(16),14526-14537.
MLA Deng, Han,et al."Targeted and Multifunctional Technology for Identification between Hepatocellular Carcinoma and Liver Cirrhosis".ACS APPLIED MATERIALS & INTERFACES 11.16(2019):14526-14537.
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