CASIA OpenIR
Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis
Xu, Jinshun1,2,3; Chen, Xueqing5; Tan, Longfei2; Fu, Changhui2; Ahmed, Muneeb4; Tian, Jie6; Dou, Jianping1; Zhou, Qunfang1; Ren, Xiangling2; Wu, Qiong2; Tang, Shunsong2; Zhou, Hongqiao2; Meng, Xianwei2; Yu, Jie1,3; Liang, Ping1,3
Source PublicationNANO LETTERS
ISSN1530-6984
2019-05-01
Volume19Issue:5Pages:2914-2927
Corresponding AuthorMeng, Xianwei(mengxw@mail.ipc.ac.cn) ; Yu, Jie(yu-jie301@hotmail.com) ; Liang, Ping(liangping301@hotmail.com)
AbstractHepatocellular carcinoma (HCC) with metastatic disease is associated with a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective in local but limited for patients with distant metastasis. In this study, the efficacy, specificity, and safety of P-selectin targeted delivery and microwave (MW) responsive drug release is investigated for development of HCC therapy. By encapsulating doxorubicin (DOX) and MW sensitizer (1-butyl-3-methylimidazolium-L-lactate, BML) into fucoidan conjugated liposomal nanoparticles (TBP@DOX), specific accumulation and prominent release of DOX in orthotopic HCC and lung metastasis are achieved with adjuvant MW exposure. This results in orthotopic HCC growth inhibition that is not only 1.95-fold higher than found for nontargeted BP@DOX and 1.6-fold higher than nonstimuli responsive TP@DOX but is also equivalent to treatment with free DOX at a 10-fold higher dose. Furthermore, the optimum anticancer efficacy against distant lung metastasis and effective prevention of widespread dissemination with a prolonged survival is described. In addition, no adverse metabolic events are identified using the TBP@DOX nanodelivery system despite these events being commonly observed with traditional DOX chemotherapy. Therefore, administering TBP@DOX with MW exposure could potentially enhance the therapeutic efficacy of thermal-chemotherapy of HCC, especially those in the advanced stages.
KeywordNanoplatform P-selectin microwave hepatocellular carcinoma metastasis
DOI10.1021/acs.nanolett.8b05202
WOS KeywordCANCER STATISTICS ; TUMOR ; NANOPARTICLES ; NANOCARRIERS ; STRATEGIES ; SORAFENIB ; PLATFORM ; THERAPY ; LIGANDS
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFC0112000] ; National Natural Science Foundation of China (NSFC)[81627803] ; National Natural Science Foundation of China (NSFC)[91859201] ; National Natural Science Foundation of China (NSFC)[81622024] ; National Natural Science Foundation of China (NSFC)[81701797] ; Beijing Natural Science Foundation[JQ18021] ; Beijing Natural Science Foundation[7192200] ; Beijing Natural Science Foundation[4161003]
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000467781900020
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24204
Collection中国科学院自动化研究所
Corresponding AuthorMeng, Xianwei; Yu, Jie; Liang, Ping
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen, Beijing 100190, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China
4.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Radiol, Lab Minimally Invas Tumor Therapies, Boston, MA 02215 USA
5.Sichuan Prov Canc Hosp, Dept Ultrasound, Chengdu 610041, Peoples R China
6.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jinshun,Chen, Xueqing,Tan, Longfei,et al. Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis[J]. NANO LETTERS,2019,19(5):2914-2927.
APA Xu, Jinshun.,Chen, Xueqing.,Tan, Longfei.,Fu, Changhui.,Ahmed, Muneeb.,...&Liang, Ping.(2019).Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis.NANO LETTERS,19(5),2914-2927.
MLA Xu, Jinshun,et al."Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis".NANO LETTERS 19.5(2019):2914-2927.
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