Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis

doi:10.1021/acs.nanolett.8b05202

	Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis
	Xu, Jinshun 1,2,3; Chen, Xueqing 5; Tan, Longfei 2; Fu, Changhui 2; Ahmed, Muneeb 4; Tian, Jie 6; Dou, Jianping 1; Zhou, Qunfang 1; Ren, Xiangling 2; Wu, Qiong 2; Tang, Shunsong 2; Zhou, Hongqiao 2; Meng, Xianwei 2; Yu, Jie 1,3; Liang, Ping 1,3
发表期刊	NANO LETTERS
ISSN	1530-6984
	2019-05-01
卷号	19 期号:5 页码:2914-2927
通讯作者	Meng, Xianwei(mengxw@mail.ipc.ac.cn) ; Yu, Jie(yu-jie301@hotmail.com) ; Liang, Ping(liangping301@hotmail.com)
摘要	Hepatocellular carcinoma (HCC) with metastatic disease is associated with a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective in local but limited for patients with distant metastasis. In this study, the efficacy, specificity, and safety of P-selectin targeted delivery and microwave (MW) responsive drug release is investigated for development of HCC therapy. By encapsulating doxorubicin (DOX) and MW sensitizer (1-butyl-3-methylimidazolium-L-lactate, BML) into fucoidan conjugated liposomal nanoparticles (TBP@DOX), specific accumulation and prominent release of DOX in orthotopic HCC and lung metastasis are achieved with adjuvant MW exposure. This results in orthotopic HCC growth inhibition that is not only 1.95-fold higher than found for nontargeted BP@DOX and 1.6-fold higher than nonstimuli responsive TP@DOX but is also equivalent to treatment with free DOX at a 10-fold higher dose. Furthermore, the optimum anticancer efficacy against distant lung metastasis and effective prevention of widespread dissemination with a prolonged survival is described. In addition, no adverse metabolic events are identified using the TBP@DOX nanodelivery system despite these events being commonly observed with traditional DOX chemotherapy. Therefore, administering TBP@DOX with MW exposure could potentially enhance the therapeutic efficacy of thermal-chemotherapy of HCC, especially those in the advanced stages.
关键词	Nanoplatform P-selectin microwave hepatocellular carcinoma metastasis
DOI	10.1021/acs.nanolett.8b05202
关键词[WOS]	CANCER STATISTICS ; TUMOR ; NANOPARTICLES ; NANOCARRIERS ; STRATEGIES ; SORAFENIB ; PLATFORM ; THERAPY ; LIGANDS
收录类别	SCI
语种	英语
资助项目	Beijing Natural Science Foundation[4161003] ; Beijing Natural Science Foundation[7192200] ; Beijing Natural Science Foundation[JQ18021] ; National Natural Science Foundation of China (NSFC)[81701797] ; National Natural Science Foundation of China (NSFC)[81622024] ; National Natural Science Foundation of China (NSFC)[91859201] ; National Natural Science Foundation of China (NSFC)[81627803] ; National Key R&D Program of China[2017YFC0112000] ; National Key R&D Program of China[2017YFC0112000] ; National Natural Science Foundation of China (NSFC)[81627803] ; National Natural Science Foundation of China (NSFC)[91859201] ; National Natural Science Foundation of China (NSFC)[81622024] ; National Natural Science Foundation of China (NSFC)[81701797] ; Beijing Natural Science Foundation[JQ18021] ; Beijing Natural Science Foundation[7192200] ; Beijing Natural Science Foundation[4161003]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000467781900020
出版者	AMER CHEMICAL SOC
引用统计	被引频次：60[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24204
专题	中国科学院分子影像重点实验室
通讯作者	Meng, Xianwei; Yu, Jie; Liang, Ping
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen, Beijing 100190, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China 4.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Radiol, Lab Minimally Invas Tumor Therapies, Boston, MA 02215 USA 5.Sichuan Prov Canc Hosp, Dept Ultrasound, Chengdu 610041, Peoples R China 6.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jinshun,Chen, Xueqing,Tan, Longfei,et al. Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis[J]. NANO LETTERS,2019,19(5):2914-2927.
APA	Xu, Jinshun.,Chen, Xueqing.,Tan, Longfei.,Fu, Changhui.,Ahmed, Muneeb.,...&Liang, Ping.(2019).Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis.NANO LETTERS,19(5),2914-2927.
MLA	Xu, Jinshun,et al."Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis".NANO LETTERS 19.5(2019):2914-2927.