CASIA OpenIR
Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients
Liu, Li1; Ji, Gang2; Li, Guanya1; Hu, Yang1; Jin, Qingchao1; Hu, Chunxin1; Zhao, Jizheng3; Meng, Qianqian1; von Deneen, Karen M.1; Chen, Antao4; Cui, Guangbin5; Wang, Huaning6; Zhao, Qingchuan2; Wu, Kaichun2; Tian, Jie1,7; Shokri-Kojori, Ehsan8; Tomasi, Dardo8; Volkow, Nora D.8; Nie, Yongzhan2; Zhang, Yi1; Wang, Gene-Jack8
Source PublicationBRAIN IMAGING AND BEHAVIOR
ISSN1931-7557
2019-06-01
Volume13Issue:3Pages:830-840
Corresponding AuthorJi, Gang(jigang@fmmu.edu.cn) ; Zhang, Yi(yizhang@xidian.edu.cn) ; Wang, Gene-Jack(gene-jack.wang@nih.gov)
AbstractObesity-related brain gray (GM) and white matter (WM) abnormalities have been reported in regions associated with food-intake control and cognitive-emotional regulation. Bariatric surgery (BS) is the most effective way to treat obesity and induce structural recovery of GM/WM density and WM integrity. It is unknown whether the surgery can promote structural changes in cortical morphometry along with weight-loss. Structural Magnetic Resonance Imaging and surface-based morphometry analysis were used to investigate BS-induced alterations of cortical morphometry in 22 obese participants who were tested before and one month post-BS, and in 21 obese controls (Ctr) without surgery who were tested twice (Baseline and One-month). Results showed that fasting plasma ghrelin, insulin, and leptin levels were significantly reduced post-BS (P<0.001). Post-BS there were significant decreases in cortical thickness in the precuneus (P-FDR<0.05) that were associated with decreases in BMI. There were also significant increases post-BS in cortical thickness in middle (MFG) and superior (SFG) frontal gyri, superior temporal gyrus (STG), insula and ventral anterior cingulate cortex (vACC); and in cortical volume in left postcentral gyrus (PostCen) and vACC (P-FDR<0.05). Post-BS changes in SFG were associated with decreases in BMI. These findings suggest that structural changes in brain regions implicated in executive control and self-referential processing are associated with BS-induced weight-loss.
KeywordObesity Bariatric surgery Cortical morphometry Linear mixed effects
DOI10.1007/s11682-018-9904-2
WOS KeywordSURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; GASTRIC BYPASS ; CORTICAL THICKNESS ; FUNCTIONAL CONNECTIVITY ; ANTERIOR CINGULATE ; BARIATRIC SURGERY ; MORBIDLY OBESE ; ADDICTION ; LEPTIN
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61431013] ; National Natural Science Foundation of China[81470816] ; National Natural Science Foundation of China[81501543] ; National Natural Science Foundation of China[81601563] ; National Natural Science Foundation of China[81730016] ; National Clinical Research Center for Digestive Diseases, Xi'an, China[2015BAI13B07] ; Intramural Research Program of the United States National Institute on Alcoholism and Alcohol Abuse[Z01AA3009]
Funding OrganizationNational Natural Science Foundation of China ; National Clinical Research Center for Digestive Diseases, Xi'an, China ; Intramural Research Program of the United States National Institute on Alcoholism and Alcohol Abuse
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000469351500024
PublisherSPRINGER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24383
Collection中国科学院自动化研究所
Corresponding AuthorJi, Gang; Zhang, Yi; Wang, Gene-Jack
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Ctr Brain Imaging, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Gastrointestinal Hosp, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
3.Northwest A&F Univ, Coll Mech & Elect Engn, Yangling 712100, Shaanxi, Peoples R China
4.Southwest Univ, Dept Psychol, Chongqing 400715, Peoples R China
5.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China
7.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
8.NIAAA, Lab Neuroimaging, 10 Ctr Dr,MSC1013,Bldg 10,Room B2L304, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Liu, Li,Ji, Gang,Li, Guanya,et al. Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients[J]. BRAIN IMAGING AND BEHAVIOR,2019,13(3):830-840.
APA Liu, Li.,Ji, Gang.,Li, Guanya.,Hu, Yang.,Jin, Qingchao.,...&Wang, Gene-Jack.(2019).Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients.BRAIN IMAGING AND BEHAVIOR,13(3),830-840.
MLA Liu, Li,et al."Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients".BRAIN IMAGING AND BEHAVIOR 13.3(2019):830-840.
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