Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease

doi:10.1016/j.nicl.2019.101723

	Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease
	Xin Zhang1 ; Sun, Yu 2; Li, Weiping 1; Liu, Bing3 ; Wu, Wenbo 1; Zhao, Hui 4; Liu, Renyuan 1,4; Zhang, Yue 2; Yin, Zhenyu 5; Yu, Tingting 5; Qing, Zhao 1; Zhu, Bin 1; Xu, Yun 4; Nedelska, Zuzana 6,7,8; Hort, Jakub 7,8; Zhang, Bing 1
发表期刊	NEUROIMAGE-CLINICAL
ISSN	2213-1582
	2019
卷号	22 页码:16
通讯作者	Zhang, Bing(zhangbing_nanjing@vip.163.com)
摘要	Brain white matter fiber bundles in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) have abnormalities not usually seen in unaffected subjects. Ideal algorithm of the localization-specific properties in white matter integrity might reveal the changes of tissue properties varying along each tract, while previous studies only detected the mean DTI parameters of each fiber. The aim of this study was to investigate whether these abnormalities of nerve fiber tracts are localized to specific regions of the tracts or spread throughout and to analyze which of the examined fiber tracts are involved in the early stages of Alzheimer's disease. In this study, we utilized VBA, TBSS as well as AFQ together to comprehensively investigate the white matter fiber impairment on 25 CE patients, 29 MCI patients and 34 normal control (NC) subjects. Two tract profiles, fractional anisotropy (FA) and mean diffusivity (MD), were extracted to evaluate the white matter integrity at 100 locations along each of 20 fiber tracts and then we validated the results with 27 CE patients, 21 MCI patients and 22 NC from the ADNI cohort. Also, we compare the AFQ with VBA and TBSS in our cohort. In comparison with NC, AD patients showed widespread FA reduction in 25% (5 /20) and MD increase in 65%(13/20) of the examined fiber tracts. The MCI patients showed a regional FA reduction in 5% (1/20) of the examined fiber tracts (right cingulum cingulate) and MD increase in 5%(1/20) of the examined fiber tracts (left arcuate fasciculus). Among these changed tracts, only the right cingulum cingulate showed widespread disruption of myelin or/and fiber axons in MCI and aggravated deterioration in AD, findings supported by FA/MD changes both by the mean and FA changes by point wise methods and TBSS. And the AFQ findings from ADNI cohort showed some similarity with our cohort, especially in the pointwise comparison of MD profiles between AD vs NC. Furthermore, the pattern of white matter abnormalities was different across neuronal fiber tracts; for example, the MCI and AD patients showed similar FA reduction in the middle part of the right cingulum cingulate, and the anterior part were not damaged. However, the left arcuate fasciculus showed MD elevation located at the temporal part of the fibers in the MCI patients and expanding to the temporal and middle part of the fibers in AD patients. So, the AFQ may be an alternative complementary method of VBA and TBSS, and may provide new insights into white matter degeneration in MCI and its association with AD.
关键词	Alzheimer's disease Mild cognitive impairment Automated fiber quantification Diffusion tensor imaging Pointwise comparison
DOI	10.1016/j.nicl.2019.101723
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; INTEGRITY ; TRACT ; HYPOMETABOLISM ; BRAIN ; DEGENERATION ; FASCICULUS ; RISK ; APOE ; MRI
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81720108022] ; National Natural Science Foundation of China[91649116] ; National Natural Science Foundation of China[81571040] ; social development project of science and technology project in Jiangsu Province[BE2016605] ; social development project of science and technology project in Jiangsu Province[BE201707] ; Key Medical Talents of the Jiangsu province ; 13th Five-Year Health Promotion Project of the Jiangsu province ; Jiangsu Provincial Key Medical Discipline (Laboratory)[ZDXKA2016020] ; Nanjing Science and Technology Development Program[YKK15065] ; Project of the Sixth Peak of Talented People[WSN-138] ; National Key R&D Program of China[2016YFC0100100] ; National Key R&D Program of China[2016YFC0100100] ; Project of the Sixth Peak of Talented People[WSN-138] ; Nanjing Science and Technology Development Program[YKK15065] ; Jiangsu Provincial Key Medical Discipline (Laboratory)[ZDXKA2016020] ; 13th Five-Year Health Promotion Project of the Jiangsu province ; Key Medical Talents of the Jiangsu province ; social development project of science and technology project in Jiangsu Province[BE201707] ; social development project of science and technology project in Jiangsu Province[BE2016605] ; National Natural Science Foundation of China[81571040] ; National Natural Science Foundation of China[91649116] ; National Natural Science Foundation of China[81720108022] ; National Natural Science Foundation of China[81720108022] ; National Natural Science Foundation of China[91649116] ; National Natural Science Foundation of China[81571040] ; social development project of science and technology project in Jiangsu Province[BE2016605] ; social development project of science and technology project in Jiangsu Province[BE201707] ; Key Medical Talents of the Jiangsu province ; 13th Five-Year Health Promotion Project of the Jiangsu province ; Jiangsu Provincial Key Medical Discipline (Laboratory)[ZDXKA2016020] ; Nanjing Science and Technology Development Program[YKK15065] ; Project of the Sixth Peak of Talented People[WSN-138] ; National Key R&D Program of China[2016YFC0100100]
项目资助者	National Natural Science Foundation of China ; social development project of science and technology project in Jiangsu Province ; Key Medical Talents of the Jiangsu province ; 13th Five-Year Health Promotion Project of the Jiangsu province ; Jiangsu Provincial Key Medical Discipline (Laboratory) ; Nanjing Science and Technology Development Program ; Project of the Sixth Peak of Talented People ; National Key R&D Program of China
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000470123000038
出版者	ELSEVIER SCI LTD
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24405
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Zhang, Bing
作者单位	1.Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Radiol, Nanjing, Jiangsu, Peoples R China 2.Southeast Univ, Lab Med Elect, Sch Biol Sci & Med Engn, Nanjing, Jiangsu, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China 5.Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Geriatr, Nanjing, Jiangsu, Peoples R China 6.St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic 7.Charles Univ Prague, Dept Neurol, Memory Clin, Fac Med 2, Prague, Czech Republic 8.Moto Univ Hosp, Prague, Czech Republic
推荐引用方式 GB/T 7714	Xin Zhang,Sun, Yu,Li, Weiping,et al. Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease[J]. NEUROIMAGE-CLINICAL,2019,22:16.
APA	Xin Zhang.,Sun, Yu.,Li, Weiping.,Liu, Bing.,Wu, Wenbo.,...&Zhang, Bing.(2019).Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease.NEUROIMAGE-CLINICAL,22,16.
MLA	Xin Zhang,et al."Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease".NEUROIMAGE-CLINICAL 22(2019):16.