CASIA OpenIR
Hypoxia-active nanoparticles used in tumor theranostic
Wang, Yaqin1,2; Shang, Wenting2; Niu, Meng1; Tian, Jie2,3; Xu, Ke1
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
2019
Volume14Pages:3705-3722
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Xu, Ke(kexu@sina.vip.com)
AbstractHypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.
Keywordprodrug tumor microenvironment metal complex bioreductive
DOI10.2147/IJN.S196959
WOS KeywordCONJUGATED POLYMER DOTS ; CARBONIC-ANHYDRASE IX ; IN-VIVO ; MITOMYCIN-C ; BIOREDUCTIVE COMPOUND ; ANTICANCER PRODRUGS ; SELECTIVE TOXICITY ; TARGETING HYPOXIA ; CELL CARCINOMA ; DRUG-DELIVERY
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2018YFC0115500] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81630053]
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000469112600001
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24409
Collection中国科学院自动化研究所
Corresponding AuthorTian, Jie; Xu, Ke
Affiliation1.China Med Univ, Affiliated Hosp 1, Dept Intervent Radiol, 155 Nanjing North St, Shenyang 110000, Liaoning, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Beihang Univ, Inst Med Interdisciplinary Innovat, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yaqin,Shang, Wenting,Niu, Meng,et al. Hypoxia-active nanoparticles used in tumor theranostic[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2019,14:3705-3722.
APA Wang, Yaqin,Shang, Wenting,Niu, Meng,Tian, Jie,&Xu, Ke.(2019).Hypoxia-active nanoparticles used in tumor theranostic.INTERNATIONAL JOURNAL OF NANOMEDICINE,14,3705-3722.
MLA Wang, Yaqin,et al."Hypoxia-active nanoparticles used in tumor theranostic".INTERNATIONAL JOURNAL OF NANOMEDICINE 14(2019):3705-3722.
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