CASIA OpenIR
A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery
Tan, Yan1,2; Zhang, Shuai-tong3,4; Wei, Jing-wei3,4; Dong, Di3; Wang, Xiao-chun1,2; Yang, Guo-qiang1,2; Tian, Jie3; Zhang, Hui1,2
Source PublicationEUROPEAN RADIOLOGY
ISSN0938-7994
2019-07-01
Volume29Issue:7Pages:3325-3337
Corresponding AuthorTian, Jie(tian@ieee.org) ; Zhang, Hui(zhanghui_mr@163.com)
AbstractObjectivesTo develop and validate a radiomics nomogram to preoperative prediction of isocitrate dehydrogenase (IDH) genotype for astrocytomas, which might contribute to the pretreatment decision-making and prognosis evaluating.MethodsOne hundred five astrocytomas (Grades II-IV) with contrast-enhanced T1-weighted imaging (CE-T1WI), T2 fluid-attenuated inversion recovery (T2FLAIR), and apparent diffusion coefficient (ADC) map were enrolled in this study (training cohort: n=74; validation cohort: n=31). IDH1/2 genotypes were determined using Sanger sequencing. A total of 3882 radiomics features were extracted. Support vector machine algorithm was used to build the radiomics signature on the training cohort. Incorporating radiomics signature and clinico-radiological risk factors, the radiomics nomogram was developed. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to assess these models. Kaplan-Meier survival analysis and log rank test were performed to assess the prognostic value of the radiomics nomogram.ResultsThe radiomics signature was built by six selected radiomics features and yielded AUC values of 0.901 and 0.888 in the training and validation cohorts. The radiomics nomogram based on the radiomics signature and age performed better than the clinico-radiological model (training cohort, AUC=0.913 and 0.817; validation cohort, AUC=0.900 and 0.804). Additionally, the survival analysis showed that prognostic values of the radiomics nomogram and IDH genotype were similar (log rank test, p<0.001; C-index=0.762 and 0.687; z-score test, p=0.062).ConclusionsThe radiomics nomogram might be a useful supporting tool for the preoperative prediction of IDH genotype for astrocytoma, which could aid pretreatment decision-making.Key Points center dot The radiomics signature based on multiparametric and multiregional MRI images could predict IDH genotype of Grades II-IV astrocytomas.center dot The radiomics nomogram performed better than the clinico-radiological model, and it might be an easy-to-use supporting tool for IDH genotype prediction.center dot The prognostic value of the radiomics nomogram was similar with that of the IDH genotype, which might contribute to prognosis evaluating.
KeywordAstrocytoma Radiomics Nomogram Isocitrate dehydrogenase Survival
DOI10.1007/s00330-019-06056-4
WOS KeywordGENOMIC ANALYSIS ; MUTATION ; GLIOMA ; FEATURES ; MRI
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation[81471652] ; National Natural Science Foundation[81771824] ; National Natural Science Foundation[81227901] ; National Natural Science Foundation[81527805] ; National Natural Science Foundation[61231004] ; National Natural Science Foundation[81671851] ; National Natural Science Foundation[81701681] ; National Natural Science Foundation[81771924] ; National Natural Science Foundation[81501616] ; National Natural Science Foundation[11705112] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2017YFC1308700] ; Precision Medicine Key Innovation Team Project[YT1601] ; Social Development Projects of Key R&D Program in Shanxi Province[201703D321016] ; Natural Science Foundation of Shanxi Province[201601D021162]
Funding OrganizationNational Natural Science Foundation ; National Key R&D Program of China ; Precision Medicine Key Innovation Team Project ; Social Development Projects of Key R&D Program in Shanxi Province ; Natural Science Foundation of Shanxi Province
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000470679400001
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24415
Collection中国科学院自动化研究所
Corresponding AuthorTian, Jie; Zhang, Hui
Affiliation1.Shanxi Med Univ, Hosp 1, Dept Radiol, Taiyuan 030001, Shanxi, Peoples R China
2.Shanxi Med Univ, Dept Med Imaging, Taiyuan 030001, Shanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Tan, Yan,Zhang, Shuai-tong,Wei, Jing-wei,et al. A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery[J]. EUROPEAN RADIOLOGY,2019,29(7):3325-3337.
APA Tan, Yan.,Zhang, Shuai-tong.,Wei, Jing-wei.,Dong, Di.,Wang, Xiao-chun.,...&Zhang, Hui.(2019).A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery.EUROPEAN RADIOLOGY,29(7),3325-3337.
MLA Tan, Yan,et al."A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery".EUROPEAN RADIOLOGY 29.7(2019):3325-3337.
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