CASIA OpenIR
Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism
Fu, Zening1,4; Tu, Yiheng2,3,4; Di, Xin5; Du, Yuhui1,6; Sui, Jing7,8; Biswal, Bharat B.5; Zhang, Zhiguo4; de lacy, N.9; Calhoun, V. D.1,10
Source PublicationNEUROIMAGE
ISSN1053-8119
2019-04-15
Volume190Pages:191-204
Corresponding AuthorFu, Zening(fzn198637@gmail.com)
AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits and restricted/repetitive behaviors and is characterized by large-scale atypical subcortical-cortical connectivity, including impaired resting-state functional connectivity between thalamic and sensory regions. Previous studies have typically focused on the abnormal static connectivity in ASD and overlooked potential valuable dynamic patterns in brain connectivity. However, resting-state brain connectivity is indeed highly dynamic, and abnormalities in dynamic brain connectivity have been widely identified in psychiatric disorders. In this study, we investigated the dynamic functional network connectivity (dFNC) between 51 intrinsic connectivity networks in 170 individuals with ASD and 195 age-matched typically developing (TD) controls using independent component analysis and a sliding window approach. A hard clustering state analysis and a fuzzy meta-state analysis were conducted respectively, for the exploration of local and global aberrant dynamic connectivity patterns in ASD. We examined the group difference in dFNC between thalamic and sensory networks in each functional state and group differences in four high-dimensional dynamic measures. The results showed that compared with TD controls, individuals with ASD show an increase in transient connectivity between hypothalamus/subthalamus and some sensory networks (right postcentral gyrus, bi paracentral lobule, and lingual gyrus) in certain functional states, and diminished global meta-state dynamics of the whole-brain functional network. In addition, these atypical dynamic patterns are significantly associated with autistic symptoms indexed by the Autism Diagnostic Observation Schedule. These converging results support and extend previous observations regarding hyperconnectivity between thalamic and sensory regions and stable whole-brain functional configuration in ASD. Dynamic brain connectivity may serve as a potential biomarker of ASD and further investigation of these dynamic patterns might help to advance our understanding of behavioral differences in this complex neurodevelopmental disorder.
DOI10.1016/j.neuroimage.2018.06.003
WOS KeywordHIGH-FUNCTIONING INDIVIDUALS ; TIME-VARYING CONNECTIVITY ; RESTING-STATE FMRI ; DEFAULT MODE NETWORK ; SPECTRUM DISORDERS ; SENTENCE COMPREHENSION ; WORKING-MEMORY ; CHILDREN ; CORTEX ; PATTERNS
Indexed BySCI
Language英语
Funding ProjectNational Institutes of Health (NIH)[R01EB006841] ; National Institutes of Health (NIH)[R01REB020407] ; National Institutes of Health (NIH)[P20GM103472] ; National Science Foundation (NSF)[1539067] ; National Center for Advancing Translational Sciences of the National Institutes of Health[KL2TR000421] ; National Natural Science Foundation of China[61703253] ; Natural Science Foundation of Shanxi Province[2016021077]
Funding OrganizationNational Institutes of Health (NIH) ; National Science Foundation (NSF) ; National Center for Advancing Translational Sciences of the National Institutes of Health ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi Province
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000467540600017
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24588
Collection中国科学院自动化研究所
Corresponding AuthorFu, Zening
Affiliation1.Mind Res Network, Albuquerque, NM 87106 USA
2.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
3.Harvard Med Sch, Boston, MA 02115 USA
4.Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China
5.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA
6.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China
7.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
9.Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
10.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
Recommended Citation
GB/T 7714
Fu, Zening,Tu, Yiheng,Di, Xin,et al. Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism[J]. NEUROIMAGE,2019,190:191-204.
APA Fu, Zening.,Tu, Yiheng.,Di, Xin.,Du, Yuhui.,Sui, Jing.,...&Calhoun, V. D..(2019).Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism.NEUROIMAGE,190,191-204.
MLA Fu, Zening,et al."Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism".NEUROIMAGE 190(2019):191-204.
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