CASIA OpenIR
Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models
Zhang, Zeyu1,2; Cai, Meishan2,3; Bao, Chengpeng2; Hu, Zhenhua2,3; Tian, Jie1,2,3
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2019-04-01
Volume17Pages:62-70
Corresponding AuthorHu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
AbstractDetecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (MCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 mu m) and imaging sensitivity (6.29 x 10 (-2 )kBq/mu l( )(18)F-FDG). The in vivo experimental data from the HCC mouse models demonstrated that the system was effective to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging. (C) 2019 Elsevier Inc. All rights reserved.
KeywordCerenkov luminescence imaging Endoscopy Image-guided surgery Hepaiocellular carcinoma (HCC)
DOI10.1016/j.nano.2018.12.017
WOS KeywordLIVER RESECTION ; TOMOGRAPHY ; SYSTEM ; CLI
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Chinese Academy of Sciences[GJJSTD20170004]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Chinese Academy of Sciences
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000467581100006
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24600
Collection中国科学院自动化研究所
Corresponding AuthorHu, Zhenhua; Tian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging,Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,et al. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,17:62-70.
APA Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,Hu, Zhenhua,&Tian, Jie.(2019).Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,17,62-70.
MLA Zhang, Zeyu,et al."Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 17(2019):62-70.
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