Knowledge Commons of Institute of Automation，CAS
| Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models | |
Zhang, Zeyu1,2 ; Cai, Meishan2,3; Bao, Chengpeng2; Hu, Zhenhua2,3; Tian, Jie1,2,3
| |
| Source Publication | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| ISSN | 1549-9634 |
| 2019-04-01 | |
| Volume | 17Pages:62-70 |
| Corresponding Author | Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org) |
| Abstract | Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (MCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 mu m) and imaging sensitivity (6.29 x 10 (-2 )kBq/mu l( )(18)F-FDG). The in vivo experimental data from the HCC mouse models demonstrated that the system was effective to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging. (C) 2019 Elsevier Inc. All rights reserved. |
| Keyword | Cerenkov luminescence imaging Endoscopy Image-guided surgery Hepaiocellular carcinoma (HCC) |
| DOI | 10.1016/j.nano.2018.12.017 |
| WOS Keyword | LIVER RESECTION ; TOMOGRAPHY ; SYSTEM ; CLI |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Chinese Academy of Sciences[GJJSTD20170004] |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Chinese Academy of Sciences |
| WOS Research Area | Science & Technology - Other Topics ; Research & Experimental Medicine |
| WOS Subject | Nanoscience & Nanotechnology ; Medicine, Research & Experimental |
| WOS ID | WOS:000467581100006 |
| Publisher | ELSEVIER SCIENCE BV |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/24600 |
| Collection | 中国科学院自动化研究所 |
| Corresponding Author | Hu, Zhenhua; Tian, Jie |
| Affiliation | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging,Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| First Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,et al. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,17:62-70. |
| APA | Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,Hu, Zhenhua,&Tian, Jie.(2019).Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,17,62-70. |
| MLA | Zhang, Zeyu,et al."Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 17(2019):62-70. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment