Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models | |
Zhang, Zeyu1,2; Cai, Meishan2,3; Bao, Chengpeng2; Hu, Zhenhua2,3; Tian, Jie1,2,3 | |
发表期刊 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE |
ISSN | 1549-9634 |
2019-04-01 | |
卷号 | 17期号:2019页码:62-70 |
摘要 | Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (MCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 mu m) and imaging sensitivity (6.29 x 10 (-2 )kBq/mu l( )(18)F-FDG). The in vivo experimental data from the HCC mouse models demonstrated that the system was effective to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging. (C) 2019 Elsevier Inc. All rights reserved. |
关键词 | Cerenkov luminescence imaging Endoscopy Image-guided surgery Hepaiocellular carcinoma (HCC) |
DOI | 10.1016/j.nano.2018.12.017 |
关键词[WOS] | LIVER RESECTION ; TOMOGRAPHY ; SYSTEM ; CLI |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] |
WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
WOS类目 | Nanoscience & Nanotechnology ; Medicine, Research & Experimental |
WOS记录号 | WOS:000467581100006 |
出版者 | ELSEVIER SCIENCE BV |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/24600 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hu, Zhenhua; Tian, Jie |
作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging,Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
第一作者单位 | 中国科学院分子影像重点实验室 |
通讯作者单位 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,et al. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,17(2019):62-70. |
APA | Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,Hu, Zhenhua,&Tian, Jie.(2019).Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,17(2019),62-70. |
MLA | Zhang, Zeyu,et al."Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 17.2019(2019):62-70. |
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