CASIA OpenIR  > 中国科学院分子影像重点实验室
Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models
Zhang, Zeyu1,2; Cai, Meishan2,3; Bao, Chengpeng2; Hu, Zhenhua2,3; Tian, Jie1,2,3
发表期刊NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2019-04-01
卷号17期号:2019页码:62-70
摘要

Detecting deep tumors inside living subject is still challenging for Cerenkov luminescence imaging (CLI). In this study, a high-sensitivity endoscopic CLI (ECLI) system was developed with a dual-mode deep cooling approach to improve the imaging sensitivity. System was characterized through a series of ex vivo studies. Furthermore, subcutaneous and orthotropic human hepatocellular carcinoma (MCC) mouse models were established for ECLI guided tumor resection in vivo. The results showed that the ECLI system had spatial resolution (62.5 mu m) and imaging sensitivity (6.29 x 10 (-2 )kBq/mu l( )(18)F-FDG). The in vivo experimental data from the HCC mouse models demonstrated that the system was effective to intraoperatively guide the surgery of deep tumors such as liver cancer. Overall, the developed system exhibits promising potential for the applications of tumor precise resection and novel nanoprobe based optical imaging. (C) 2019 Elsevier Inc. All rights reserved.

关键词Cerenkov luminescence imaging Endoscopy Image-guided surgery Hepaiocellular carcinoma (HCC)
DOI10.1016/j.nano.2018.12.017
关键词[WOS]LIVER RESECTION ; TOMOGRAPHY ; SYSTEM ; CLI
收录类别SCI
语种英语
资助项目Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Beijing Nova Program[Z181100006218046] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81527805] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672]
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号WOS:000467581100006
出版者ELSEVIER SCIENCE BV
七大方向——子方向分类医学影像处理与分析
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/24600
专题中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging,Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位中国科学院分子影像重点实验室
通讯作者单位中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,et al. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,17(2019):62-70.
APA Zhang, Zeyu,Cai, Meishan,Bao, Chengpeng,Hu, Zhenhua,&Tian, Jie.(2019).Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,17(2019),62-70.
MLA Zhang, Zeyu,et al."Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 17.2019(2019):62-70.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Endoscopic Cerenkov (2525KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Zeyu]的文章
[Cai, Meishan]的文章
[Bao, Chengpeng]的文章
百度学术
百度学术中相似的文章
[Zhang, Zeyu]的文章
[Cai, Meishan]的文章
[Bao, Chengpeng]的文章
必应学术
必应学术中相似的文章
[Zhang, Zeyu]的文章
[Cai, Meishan]的文章
[Bao, Chengpeng]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Endoscopic Cerenkov luminescence imaging and image-guided tumor.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。