A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging

doi:10.21037/tcr.2019.03.19

	A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging
	Song, Xiaodong 1,2; Shao, Zili 1; Han, Menglin 1; Liang, Huihong 1
发表期刊	TRANSLATIONAL CANCER RESEARCH
ISSN	2218-676X
	2019-04-01
卷号	8 期号:2 页码:583-591
通讯作者	Liang, Huihong(beanth@163.com)
摘要	Background: Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy in humans. Although early-stage CCA can be managed with surgery, CCA is considered incurable at advanced stages and results in poor quality of life and overall survival. A good orthotopic CCA animal model is essential to perform basic studies investigating CCA in order to understand the molecular pathways that underlie cancer development, and to develop new therapies for the prevention and treatment of CCA. However, to the best of our knowledge, orthotopic extrahepatic CCA animal models have not yet been reported in the literature. Methods: In this study, we established an orthotopic extrahepatic CCA model in mice using a two-step surgical procedure. Results: The characteristics of this model were confirmed using molecular imaging and histological analysis. Conclusions: We believe that this CCA. animal model, which can be established quickly, easily, and with good reproducibility, will help guide research on novel diagnostic and treatment strategies for extrahepatic CCA.
关键词	Extrahepatic cholangiocarcinoma (extrahepatic CCA) xenograft orthotopic mice model molecular imaging
DOI	10.21037/tcr.2019.03.19
关键词[WOS]	HILAR CHOLANGIOCARCINOMA ; TARGETED DELIVERY ; TUMOR-GROWTH ; CELLS ; SENSITIVITY ; MANAGEMENT
收录类别	SCI
语种	英语
资助项目	Guangzhou medical science and technology project[20171A010304] ; Guangzhou medical science and technology project[20171A010304]
项目资助者	Guangzhou medical science and technology project
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000466506700028
出版者	AME PUBL CO
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24911
专题	中国科学院分子影像重点实验室
通讯作者	Liang, Huihong
作者单位	1.Guangzhou Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, 250 Changgang Rd, Guangzhou 510260, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Song, Xiaodong,Shao, Zili,Han, Menglin,et al. A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging[J]. TRANSLATIONAL CANCER RESEARCH,2019,8(2):583-591.
APA	Song, Xiaodong,Shao, Zili,Han, Menglin,&Liang, Huihong.(2019).A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging.TRANSLATIONAL CANCER RESEARCH,8(2),583-591.
MLA	Song, Xiaodong,et al."A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging".TRANSLATIONAL CANCER RESEARCH 8.2(2019):583-591.