Cortical thinning and flattening in schizophrenia and their unaffected parents

doi:10.2147/NDT.S195134

	Cortical thinning and flattening in schizophrenia and their unaffected parents
	Yan, Jing 1; Cui, Yue2,3 ; Li, Qianqian 1; Tian, Lin 4,5; Liu, Bing2,3 ; Jiang, Tianzi2,3 ; Zhang, Dai1,6,7 ; Yan, Hao 1
发表期刊	NEUROPSYCHIATRIC DISEASE AND TREATMENT
	2019
卷号	15 页码:935-946
通讯作者	Zhang, Dai(daizhang@bjmu.edu.cnl) ; Yan, Hao(hao_y@bjmu.edu.cn)
摘要	Background: Schizophrenia is a neurodevelopmental disorder with high heritability. Widespread cortical thinning has been identified in schizophrenia, suggesting that it is a result of cortical development deficit. However, the findings of other cortical morphological indexes of patients are inconsistent, and the research on their relationship with genetic risk factors for schizophrenia is rare. Methods: In order to investigate cortical morphology deficits and their disease-related genetic liability in schizophrenia, we analyzed a sample of 33 patients with schizophrenia, 60 biological parents of the patients, as well as 30 young controls for patients and 28 elderly controls for parents with age, sex and education level being well-matched. We calculated vertex-wise measurements of cortical thickness, surface area, local gyrification index, sulcal depth, and their correlation with the clinical and cognitive characteristics. Results: Widespread cortical thinning of the fronto-temporo-parietal region, sulcal flattening of the insula and gyrification reduction of the frontal cortex were observed in schizophrenia patients. Conjunction analysis revealed that patients with schizophrenia and their parents shared significant cortical thinning of bilateral prefrontal and insula, left lateral occipital and fusiform regions (Monte Carlo correction, P<0.05), as well as a trend-level sulcal depth reduction mainly in bilateral insula and occipital cortex. We observed comprehensive cognitive deficits in patients and similar impairment in the speed of processing of their unaffected parents Significant associations between lower processing speed and thinning of the frontal cortex and flattening of the parahippocampal gyms were found in patients and their parents, respectively. However, no significant correlation between abnormal measurements of cortical morphology and clinical characteristics was found. Conclusion: The results suggest that cortical morphology may be susceptible to a genetic risk of schizophrenia and could underlie the cognitive dysfunction in patients and their unaffected relatives. The abnormalities shared with unaffected parents allow us to better understand the disease-specific genetic effect on cortical development.
关键词	schizophrenia first-degree relatives cortical thickness sulcus depth insula speed of processing
DOI	10.2147/NDT.S195134
关键词[WOS]	CONSENSUS COGNITIVE BATTERY ; CEREBRAL-CORTEX ; NEURON NUMBER ; SURFACE-AREA ; THICKNESS ; ABNORMALITIES ; VOLUME ; GYRIFICATION ; CINGULATE ; SYMPTOMS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81370032] ; National Natural Science Foundation of China[81771443] ; National Natural Science Foundation of China[91432304] ; National Natural Science Foundation of China[31771076] ; National Natural Science Foundation of China[81370032] ; National Natural Science Foundation of China[81771443] ; National Natural Science Foundation of China[91432304] ; National Natural Science Foundation of China[31771076]
项目资助者	National Natural Science Foundation of China
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000464704700001
出版者	DOVE MEDICAL PRESS LTD
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24921
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Zhang, Dai; Yan, Hao
作者单位	1.Peking Univ, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Inst Mental Hlth,Hosp 6, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Nanjing Med Univ, Dept Psychiat, Wuxi Mental Hlth Ctr, Wuxi 214151, Peoples R China 5.Nanjing Med Univ, Wuxi Tongren Int Rehabil Hosp, Wuxi Mental Hlth Ctr, Wuxi 214151, Peoples R China 6.Peking Univ, Peking Tsinghua Joint Ctr Life Sci, Beijing 100871, Peoples R China 7.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Yan, Jing,Cui, Yue,Li, Qianqian,et al. Cortical thinning and flattening in schizophrenia and their unaffected parents[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2019,15:935-946.
APA	Yan, Jing.,Cui, Yue.,Li, Qianqian.,Tian, Lin.,Liu, Bing.,...&Yan, Hao.(2019).Cortical thinning and flattening in schizophrenia and their unaffected parents.NEUROPSYCHIATRIC DISEASE AND TREATMENT,15,935-946.
MLA	Yan, Jing,et al."Cortical thinning and flattening in schizophrenia and their unaffected parents".NEUROPSYCHIATRIC DISEASE AND TREATMENT 15(2019):935-946.