CASIA OpenIR
Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus
Zhang, Yi1; Ji, Gang2; Li, Guanya1; Hu, Yang1; Liu, Li1; Jin, Qingchao1; Meng, Qianqian1,3; Zhao, Jizheng1; Yuan, Kai1; Liu, Jixn4; von Deneen, Karen M.1; Chen, Antao4; Cui, Guangbin5; Wang, Huaning6; Zhao, Qingchuan2; Wu, Kaichun2; Tian, Jie1,7; Manza, Peter8; Tomasi, Dardo8; Volkow, Nora D.8; Nie, Yongzhan2; Wang, Gene-Jack8
Source PublicationINTERNATIONAL JOURNAL OF OBESITY
ISSN0307-0565
2019-04-01
Volume43Issue:4Pages:842-851
Corresponding AuthorZhang, Yi(yizhang@xidian.edu.cn) ; Ji, Gang(yongznie@fmmu.edu.cn) ; Wang, Gene-Jack(gene-jack.wang@nih.gov)
AbstractBackground/objective: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery to treat obesity, and involves removal of the gastric fundus where ghrelin is mainly produced. Ghrelin stimulates appetite and regulates food intake through its effect on the hypothalamus and hippocampus (HIPP). While ghrelin's role on the hypothalamus has been explored, little is known about its role on HIPP. We tested the hypothesis that LSG-induced reductions in ghrelin levels would be associated with changes in HIPP activity. Subjects/methods: Brain activity was measured with amplitude of low-frequency fluctuations (ALFF) captured with resting-state functional magnetic resonance imaging (fMRI) in 30 obese participants, both before and after 1-month of LSG, and in 26 obese controls without surgery that were studied at baseline and 1-month later. A two-way analysis of variance (ANOVA) was performed to model the group and time effects on ALFF and resting-state functional connectivity. Results: One-month post-LSG there were significant decreases in appetite, body mass index (BMI), fasting plasma ghrelin and leptin levels, anxiety, and ALFF in HIPP and ALFF increases in posterior cingulate cortex (PCC, P-FWE < 0. 05) . Decreases in HIPP ALFF correlated positively with decreases in fasting ghrelin and anxiety, and increases in PCC ALFF correlated positively with decreases in anxiety. Seed-voxel correlation analysis showed stronger connectivity between HIPP and insula, and between PCC and dorsolateral prefrontal cortex (DLPFC) post-LSG. Conclusions: These findings suggest that ghrelin effects in HIPP modulate connectivity with the insula, which processes interoception and might be relevant to LSG-induced reductions in appetite/anxiety. Role of LSG in PCC and its enhanced connectivity with DLPFC in improving self-regulation following LSG requires further investigation.
DOI10.1038/s41366-018-0126-x
WOS KeywordLAPAROSCOPIC SLEEVE GASTRECTOMY ; MORBIDLY OBESE-PATIENTS ; GASTRIC BYPASS-SURGERY ; WEIGHT-LOSS ; FUNCTIONAL CONNECTIVITY ; DEFAULT MODE ; ACYL-GHRELIN ; BRAIN ; FOOD ; VALIDATION
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61431013] ; National Natural Science Foundation of China[81470816] ; National Natural Science Foundation of China[81601563] ; National Natural Science Foundation of China[81501543] ; National Natural Science Foundation of China[81730016] ; National Clinical Research Center for Digestive Diseases, Xi'an, China[2015BAI13B07] ; Intramural Research Program of the United States National Institute on Alcoholism and Alcohol Abuse[Z01AA3009]
Funding OrganizationNational Natural Science Foundation of China ; National Clinical Research Center for Digestive Diseases, Xi'an, China ; Intramural Research Program of the United States National Institute on Alcoholism and Alcohol Abuse
WOS Research AreaEndocrinology & Metabolism ; Nutrition & Dietetics
WOS SubjectEndocrinology & Metabolism ; Nutrition & Dietetics
WOS IDWOS:000462994400022
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24947
Collection中国科学院自动化研究所
Corresponding AuthorZhang, Yi; Ji, Gang; Wang, Gene-Jack
Affiliation1.Xidian Univ, Ctr Brain Imaging, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Gastrointestinal Hosp, Xian 710032, Shaanxi, Peoples R China
3.Northwest A&F Univ, Coll Mech & Elect Engn, Yangling 712100, Shaanxi, Peoples R China
4.Southwest Univ, Dept Psychol, Chongqing 400715, Peoples R China
5.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China
7.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
8.NIAAA, Lab Neuroimaging, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Zhang, Yi,Ji, Gang,Li, Guanya,et al. Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus[J]. INTERNATIONAL JOURNAL OF OBESITY,2019,43(4):842-851.
APA Zhang, Yi.,Ji, Gang.,Li, Guanya.,Hu, Yang.,Liu, Li.,...&Wang, Gene-Jack.(2019).Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus.INTERNATIONAL JOURNAL OF OBESITY,43(4),842-851.
MLA Zhang, Yi,et al."Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus".INTERNATIONAL JOURNAL OF OBESITY 43.4(2019):842-851.
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