CASIA OpenIR
Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis
Tian, Yuan1,4; Liu, Zhenyu2; Tang, Zhenchao2,5; Li, Mingge1; Lou, Xin1; Dong, Enqing5; Liu, Gang1; Wang, Yulin1; Wang, Yan1; Bian, Xiangbin1; Wei, Shihui3; Tian, Jie2,6; Ma, Lin1
Source PublicationJOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN1053-1807
2019-05-01
Volume49Issue:5Pages:1365-1373
Corresponding AuthorWei, Shihui(weishihui706@hotmail.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Ma, Lin(cjr.malin@vip.163.com)
AbstractBackground Neuromyelitis optica-optic neuritis (NMO-ON) patients are routinely treated with intravenous methylprednisolone (IVMP). For the patients nonresponsive to IVMP, more effective but aggressive therapy of plasma exchange (PE) should be employed instead of IVMP in the first line. Purpose To assess the visual outcomes of NMO-ON patients after IVMP by radiomics analysis of whole brain diffusion tensor imaging (DTI) data. Study Type Retrospective. Population In all, 57 NMO-ON patients receiving IVMP therapy for 3 days. Field Strength/Sequence 3.0T; DTI images acquired by a single-shot echo planar image sequence; T-1 images acquired by 3D fast spoiled gradient echo (3D-FSPGR) MRI. Assessment In all, 200 DTI measures were extracted from the DTI data and employed as features to construct a radiomics assessment model for visual outcomes of NMO-ON patients after IVMP. The assessment performance was evaluated by area under the receiver operating characteristic curve (AUC), classification accuracy (ACC), sensitivity, specificity, and positive and negative predicted values (PPV and NPV). The selected DTI measures would reveal the white matter impairments related to visual recovery of NMO-ON patients. Statistical Tests The relationship between the selected DTI measures and the clinical visual characteristics were investigated by Pearson correlation, Spearman's rank correlation, and one-way analysis of variance analysis. Results The radiomics model obtained an ACC of 73.68% (P = 0.002), AUC of 0.7931, sensitivity of 0.6207, specificity of 0.8571, PPV of 0.8182, and NPV of 0.6857 in assessing visual outcomes of the NMO-ON patients after IVMP treatment. The selected DTI measures revealed white matter impairments related to the visual outcomes in the white matter tracts of vision-relevant regions, motor-related regions, and corpus callosum. The white matter impairments were found significantly correlated with the disease duration and the length of lesions in the optic nerve. Data Conclusion Radiomics analysis of DTI data has great potential in assessing visual outcomes of NMO-ON patients after IVMP therapy.
Keywordneuromyelitis optica optic neuritis intravenous methylprednisolone radiomics white matter visual outcomes
DOI10.1002/jmri.26326
WOS KeywordWHITE-MATTER ; DIFFUSION ; DAMAGE ; NERVE
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Plan of China[2017YFA0205200] ; National Key Research and Development Plan of China[2016YFC0103001] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81501549] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81772012] ; Beijing Municipal Science & Technology Commission[Z171100000117023] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; 309th Hospital of Chinese People's Liberation Army[2014ZD-003]
Funding OrganizationNational Key Research and Development Plan of China ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; 309th Hospital of Chinese People's Liberation Army
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000464390200015
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/24955
Collection中国科学院自动化研究所
Corresponding AuthorWei, Shihui; Tian, Jie; Ma, Lin
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Ophthalmol, Beijing, Peoples R China
4.Chinese Peoples Liberat Army, Hosp 309, Dept Radiol, Beijing, Peoples R China
5.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai, Shandong, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Tian, Yuan,Liu, Zhenyu,Tang, Zhenchao,et al. Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2019,49(5):1365-1373.
APA Tian, Yuan.,Liu, Zhenyu.,Tang, Zhenchao.,Li, Mingge.,Lou, Xin.,...&Ma, Lin.(2019).Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis.JOURNAL OF MAGNETIC RESONANCE IMAGING,49(5),1365-1373.
MLA Tian, Yuan,et al."Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis".JOURNAL OF MAGNETIC RESONANCE IMAGING 49.5(2019):1365-1373.
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