Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study

doi:10.1080/02713683.2018.1540642

	Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study
	Yan, Xiaohe 2,3; Wang, Yun 4,5,6,7; Xu, Lijuan 8,9; Liu, Yong8,9 ; Song, Shaojie 1; Ding, Kun 1; Zhou, Yuan 7; Jiang, Tianzi8,9 ; Lin, Xiaoming 1
发表期刊	CURRENT EYE RESEARCH
ISSN	0271-3683
	2019-03-04
卷号	44 期号:3 页码:316-323
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Lin, Xiaoming(linxiaom@mail.sysu.edu.cn)
摘要	Purpose: The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). Methods: A prospective, observational study was conducted. Ten patients with comitant exotropia and eleven matched healthy subjects underwent resting-state fMRI with their eyes closed. Resting-state fMRI was performed using a 3.0 T MR scanner. The primary visual cortex was subdivided into anterior and posterior subdivisions. The resting-state functional connectivities within the primary visual cortex and between the primary visual cortex and other cortical areas were calculated for each group and compared between the strabismic and normal control groups. fMRI data were analyzed using Statistical Parametric Mapping software and Analysis of Functional NeuroImages software. Results: Compared with the normal controls, patients with comitant strabismus had increased functional connectivity between the posterior primary visual cortex and other cortical areas, especially the visual cortex [Brodmann area 19 (BA19)] and other oculomotor regions, such as the frontal eye field (BA6). Conclusions: The fMRI results suggest that ongoing and permanent cortical changes occur in patients with comitant strabismus. Disrupted brain functional connectivities are associated with abnormal eye movement and loss of stereopsis. Our study provides a neurological basis for understanding the pathophysiology of comitant strabismus, which may prompt new areas of research to more precisely define this basis and extend these findings to enhance diagnosis and treatment.
关键词	Functional connectivity primary visual cortex comitant strabismus resting-state functional magnetic resonance imaging (fMRI)
DOI	10.1080/02713683.2018.1540642
关键词[WOS]	EYES OPEN ; HUMAN BRAIN ; PARCELLATION ; SUPPRESSION ; SEGREGATION ; TOPOGRAPHY ; PLASTICITY ; AMBLYOPIA ; EXOTROPIA ; ESOTROPIA
收录类别	SCI
语种	英语
资助项目	Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20150730150557658] ; Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20170413143051465] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2012B061700084] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2013B020307004] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2015A020212002] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2016A020216002] ; Natural Science Foundation of Guangdong[2014A030310084] ; National Natural Science Foundation of China[81500708] ; Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20150730150557658] ; Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20170413143051465] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2012B061700084] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2013B020307004] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2015A020212002] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2016A020216002] ; Natural Science Foundation of Guangdong[2014A030310084] ; National Natural Science Foundation of China[81500708]
项目资助者	Research Foundation of Science and Technology Plan Project, Shenzhen, China ; Research Foundation of Science and Technology Plan Project, Guangdong, China ; Natural Science Foundation of Guangdong ; National Natural Science Foundation of China
WOS研究方向	Ophthalmology
WOS类目	Ophthalmology
WOS记录号	WOS:000460060500011
出版者	TAYLOR & FRANCIS INC
七大方向——子方向分类	脑网络分析
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24987
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Jiang, Tianzi; Lin, Xiaoming
作者单位	1.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China 2.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Key Lab Ophthalmol, Shenzhen, Peoples R China 3.Shenzhen Univ, Sch Optometry, Shenzhen, Peoples R China 4.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 6.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci & Magnet Resonance Imaging Res, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所; 模式识别国家重点实验室
推荐引用方式 GB/T 7714	Yan, Xiaohe,Wang, Yun,Xu, Lijuan,et al. Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study[J]. CURRENT EYE RESEARCH,2019,44(3):316-323.
APA	Yan, Xiaohe.,Wang, Yun.,Xu, Lijuan.,Liu, Yong.,Song, Shaojie.,...&Lin, Xiaoming.(2019).Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study.CURRENT EYE RESEARCH,44(3),316-323.
MLA	Yan, Xiaohe,et al."Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study".CURRENT EYE RESEARCH 44.3(2019):316-323.