CASIA OpenIR
Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging
Xi, Yi-bin1; Kang, Xiao-wei1; Wang, Ning1; Liu, Ting-ting1; Zhu, Yuan-qiang1; Cheng, Guang2; Wang, Kai2; Li, Chen1; Guo, Fan1,3; Yin, Hong1
Source PublicationEUROPEAN JOURNAL OF RADIOLOGY
ISSN0720-048X
2019-03-01
Volume112Pages:59-64
Corresponding AuthorGuo, Fan(guofan@fmmu.edu.cn) ; Yin, Hong(yinhong@fmmu.edu.cn)
AbstractBackground and purpose: Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters to differentiate PCNSL from high-grade glioma (HGG) and brain metastasis. Materials and methods: Eight patients with PCNSL, twenty one patients with HGG and six brain metastasis underwent preoperative 3.0-T MR imaging including conventional, ASL and DCE. Quantitative parameters including relative cerebral blood flow (rCBF), extravascular extracellular volume fraction (V-e) and the volume transfer constant (K-trans) among PCNSL, HGG and metastasis were compared with a one-way analysis of variance. In addition, the area under the receiver-operating characteristic (ROC) curve (AUC) was constructed to evaluate the differentiation diagnostic performance of each parameter and the combination. Results: The PCNSL demonstrated significantly lower rCBF, higher K-trans and V-e compared with HGG and metastasis. For the ROC analyses, both K-trans and rCBF had good diagnostic performance for discriminating PCNSL from HGG and metastasis, with the AUC of 0.880 and 0.889. With the combination of rCBF and K-trans the diagnostic ability for PCNSL was improved with AUC of 0.986. Conclusion: rCBF and K-trans are useful parameters for differentiating PCNSL from HGG and brain metastasis. The combination of rCBF and K-trans further helps to improve the diagnostic performance of PCNSL.
KeywordPrimary central nervous system lymphoma High-grade glioma Metastasis Arterial spin labeling Dynamic contrast-enhanced perfusion
DOI10.1016/j.ejrad.2019.01.008
WOS KeywordPRIMARY CNS LYMPHOMA ; GLIOBLASTOMA-MULTIFORME ; PERFUSION MRI ; DIFFUSION ; PERMEABILITY ; VOLUME ; TUMORS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81400952] ; National Natural Science Foundation of China[81372457]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000458752500009
PublisherELSEVIER IRELAND LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25031
Collection中国科学院自动化研究所
Corresponding AuthorGuo, Fan; Yin, Hong
Affiliation1.Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Xijing Inst Clin Neurosci, Dept Neurosurg, Xian 710032, Shaanxi, Peoples R China
3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xi, Yi-bin,Kang, Xiao-wei,Wang, Ning,et al. Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging[J]. EUROPEAN JOURNAL OF RADIOLOGY,2019,112:59-64.
APA Xi, Yi-bin.,Kang, Xiao-wei.,Wang, Ning.,Liu, Ting-ting.,Zhu, Yuan-qiang.,...&Yin, Hong.(2019).Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging.EUROPEAN JOURNAL OF RADIOLOGY,112,59-64.
MLA Xi, Yi-bin,et al."Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging".EUROPEAN JOURNAL OF RADIOLOGY 112(2019):59-64.
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